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new sleep med/orexin antagonist??

Discussion in 'General Treatment' started by heapsreal, Jun 14, 2012.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Posting this after reading this from prohealth board, http://www.prohealth.com/me-cfs/library/showarticle.cfm?libid=17047

    Suvorexant (MK-4305) is an orexin receptor antagonist in development by Merck & Co.[1][2][3] The drug works by turning off wakefulness rather than by inducing sleep.[4] This drug for sleep disorders has completed three Phase III trials[5] and is one of several such compounds currently in development, the others being Actelion's ACT-078573 and GlaxoSmithKline's SB-649,868

    Sounds interesting, i wonder how much this will cost when it first comes out.

    cheers!!!
     
    taniaaust1 and Little Bluestem like this.
  2. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    Interesting. Wonder how long til it comes to market, if it gets approved. I will have to google....

    All I know about orexin is that it is somehow connected to narcolespy......but I cant remember if they had a deficiency or too much of it?

    "Turning off wakefulness" is what I need. My brain just will not turn off.
     
  3. Sushi

    Sushi Senior Member Albuquerque

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    Sounds a bit like
    Propofol--which is blissful, instant lights-out! :rofl: Too bad it could kill you without an aenesthesiologist involved.

    Sushi
     
  4. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    Ah hell, I hope not!

    I actually hope this may be something promising, I am in need of a miracle sleep drug.
     
  5. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    From my understanding orexin keeps one alert, these new sleep meds are able to block this, so in a strange way this med isnt putting one to sleep like traditional meds but what it does is stops people being alert, i suppose making it easier to sleep.
    I didnt think propofol worked like that, but i dont know much about it.

    cheers!!!
     
  6. *GG*

    *GG* Senior Member

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    Have you tried anti-depressants?

    GG
     
  7. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    Turning off wakefulness is an interesting idea. I think our up-regulated autonomic nervous systems could be considered over-wakefulness.
     
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Could be the off button we have been searching for.
    Lets hope it comes out quicker then ampligen, it should cause it will make alot more money for big pharma.

    cheers!!!
     
  9. taniaaust1

    taniaaust1

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    It it works by shutting off alertness.. I wonder how safe this drug would be in the event of a fire in ones house
     
  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    U would think it would be like normal sleep and able to wake for those things.

    Doesnt sound like someone being sedated like other traditional sleep meds or xyrem even alcohol which i suppose have the same problem if there was a fire.

    Time will tell, if its in phase 3 trials, does anyone know an estimated time a med like this would be approved??

    cheers!!!
     
  11. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Paste and copy from wiki, so u wouldnt think it was too far away from coming to market??

    Clinical trials involving new drugs are commonly classified into four phases. Each phase of the drug approval process is treated as a separate clinical trial. The drug-development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases 1, 2, and 3, it will usually be approved by the national regulatory authority for use in the general population.
    • Phase 1: Screening for safety
    • Phase 2: Establishing the testing protocol
    • Phase 3: Final testing
    • Phase 4: Postapproval studies
    Clinical trials are conducted in phases. The trials at each phase have different purposes and help scientists answer different questions:
    In Phase 1 trials, researchers test an experimental drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
    In Phase 2 trials, the experimental study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
    In Phase 3 trials, the experimental study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the experimental drug or treatment to be used safely.
    In Phase 4 trials, postmarketing studies delineate additional information, including the drug's risks, benefits, and optimal use.
     
  12. TheMoonIsBlue

    TheMoonIsBlue Senior Member

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    Looks like if it is approved it wont be available until mid 2013
     

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