The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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New research sheds light on how the body regulates fundamental neuro-hormone

Discussion in 'Other Health News and Research' started by leela, Feb 11, 2014.

  1. leela

    leela Slow But Hopeful

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    http://www.eurekalert.org/pub_releases/2014-02/uob-nrs021014.php

    PUBLIC RELEASE DATE:

    11-Feb-2014
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    Contact: Philippa Walker
    philippa.walker@bristol.ac.uk
    44-117-928-8086
    University of Bristol
    New research sheds light on how the body regulates fundamental neuro-hormone
    New research has revealed a previously unknown mechanism in the body which regulates a hormone that is crucial for motivation, stress responses and control of blood pressure, pain and appetite. The breakthrough could be used to design drugs to help fight health problems connected with these functions in the future.

    Researchers at the University of Bristol and University College London found that lactate – essentially lactic acid – causes cells in the brain to release more noradrenaline (norepinephrine in US English), a hormone and neurotransmitter which is fundamental for brain function. Without it people can hardly wake up or focus on anything.

    Production of lactate can be triggered by muscle use, which reinforces the connection between exercise and positive mental wellbeing.

    Lactate was first discovered in sour milk by Swedish chemist, Carl Wilhelm Scheele in 1780. It is produced naturally by the body, for example when muscles are at work. In the brain, it has always been regarded as an energy source which can be delivered to neurones as fuel to keep them working when brain activity increases.

    This research, published today [11 February] in Nature Communications, identifies a secondary function for lactate as a signal between brain cells. It implies that there is an as yet unknown receptor for lactate in the brain which must be present on noradrenaline cells to make them sensitive to lactate.

    Professor Sergey Kasparov, from Bristol University's School of Physiology and Pharmacology, said: "Our findings suggest that lactate has more than one incarnation - in addition to its role as an energy source, it is also a signal to neurones to release more noradrenaline."

    Dr Anja Teschemacher, also from the University of Bristol, added: "The next big task is to identify the receptor which mediates this effect because this will help to design drugs to block or stimulate this response. If we can regulate the release of noradrenaline – which is absolutely fundamental for brain function - then this could have important implications for the treatment of major health problems such as stress, blood pressure, pain and depression."

    Astrocytes, small non-neuronal star-shaped cells in the brain and spinal cord, are the principle source of brain lactate. The discovery that astrocytes communicate directly with neurones opens up a whole new area of pharmacology which has been little explored.

    ###


    The research was funded by the British Heart Foundation (BHF), the Medical Research Council (MRC), The Wellcome Trust and the Biotechnology and Biological Sciences Research Council (BBSRC).

    Paper:

    'Lactate-mediated glia-neuronal signaling in the mammalian brain' by F. Tang, S. Lane, A. Korsak, J.F.R. Paton, A.V. Gourine, S. Kasparov & A.G. Teschemacher, in Nature Communications DOI: 10.1038/ncomms4284
     
  2. aimossy

    aimossy Senior Member

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    Wait for it.......:wide-eyed::wide-eyed::wide-eyed::wide-eyed::jaw-drop: will have to read fully later though.....nice one @leela :DThankyou.
     
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  3. WoolPippi

    WoolPippi Senior Member

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    So interesting! Thanks. Lots to think about!

    The article is about lactate as a neurotransmitter and the opinion seems to be that more active noradrenaline is desirable... (I wonder if it is.)

    Here's the link to the research paper
    Oh my, they're on to something! Injecting lactate in the brain -locus coeruleus- gets the same excitatory reaction as L-glutamate would have done.

    And I'd like to park this post by Hyperlipid here as it has an explaining picture about the energy-side of lactate in the brain. It discusses mitochondria, ketones and FADH2:NADH ratio which all seem connected to this. Hope you don't mind.
     
    Last edited: Feb 11, 2014
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  4. leela

    leela Slow But Hopeful

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    Wow @WoolPippi , that's a great post--and so are the comments! Much to consider...
    Thanks for finding the full paper, too.
     
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  5. biophile

    biophile Places I'd rather be.

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    If I recall, some studies but not others find elevated noradrenaline in CFS? Of course, some believe this is due to an abnormal stress response or wherever, but considering that there is also evidence for elevated lactate both in the brain at rest and in the muscles after exercise in CFS, perhaps this is another explanation for elevated noradrenaline?
     

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