Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study Cho, H. J., Kivimäki, M., Bower, J. E., & Irwin, M. R. (2013). Psychological medicine, 43(08), 1773-1783. (Click on title for full text link) This is potentially important work. The absence of biomarkers associated with fatigue severity has been used to argue that it is a largely due to psychological factors. This is true in CFS, and also in other diseases that feature fatigue as a prominent symptom (e.g., MS, lupus). If we can find a biomarker that predicts fatigue at the group level - even if it can't fully predict how much fatigue any particular individual will experience - then that's a huge step forward.