Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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New....Posting Genetic Genie Resuts

Discussion in 'Genetic Testing and SNPs' started by debs, Oct 14, 2015.

  1. debs

    debs

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    I need help deciphering these. I started looking these up individually and ended up just confusing myself immensely. Can anyone help me understand what they mean and what if anything I can do to remedy any or all?
    I feel like I need Genetic Genie for dummies, or something! And also in looking at my lists like I'll be close to writing my own book of letters and numbers.
    My fingers are crossed, along with my eyes, that I'm not too horribly bad off having these!
    Thank you, anyone and everyone, for having a look.
    Methylation Profile: Red:
    COMT V158M AA
    COMT H62H TT
    VDR Taq AA
    MAO A R297R TT
    MTRR A66G GG
    Yellow:
    MTHFR A 1298C GT
    MTR A2756G AG
    MTRR A664A AG
    BHMT-02 CT
    BHMT-08 CT
    CBS C699T AG
    CBS A360A

    Detox Profile: Red:
    CYP2D6 S486T GG
    CYP3A4*1B CC
    Yellow:
    CYP1A2 164A>C AC
    CYP1B1 L432V CG
    CYP1B1 R48G CG
    CYP2C19*17 CT
    CYP2D6 100C>T AG
    CYP2D6 2850C>T AG
    GSTP1 I 105V AG
    SOD2 A16V AG
    NAT2 I 114T CT
    NAT2 R197Q AG
    NAT2K268R AG
     
  2. TheChosenOne

    TheChosenOne Senior Member

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    The COMT + MAOA combination is a potential problem. I have severe issues tolerating methylation donors, so you might have them too. I really hate the COMT gene :(
    It's best to increase supplements slowly. I've tried a lot of supplements to stimulate COMT. The one that made a huge difference is lithium orotate.
    You only have one minor MTHFR mutation, so you may not need methylfolate. But methylfolate is good for other things (like the protection of BH4, which can be low in people with ME/CFS).
    You have mutations with regard to methylB12, so it's something you probably need.
    Start slow (eg 50 mcg).
    BHMT is just a minor issue as it is not active in the brain. Phosphatidylcholine or TMG support this pathway.
    If you get signs of anxiety, irritability, anger or mood swings, it means you are taking too much methyl donors with regard to COMT/MAOA status.

    Detox:
    SOD2: superoxide dismutase. This is mitochondrial protection against superoxide, oxidative stress and inflammation. Supplementing manganese supports SOD2.
    GSTP1: This is an important one. It uses reduced glutathione for detoxification.
    I have no idea about the others.
     
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  3. caledonia

    caledonia

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    Cincinnati, OH, USA
    Click on the link in my signature to find a page of useful methylation documents and links. One of those is called the SNPs Interpretation Guide.
     
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  4. debs

    debs

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    No lies.............I am close to tears!
    Needless to say I have been doing a lot of reading. Thank you so much ChosenOne and Caledonia.
    My main concern right now is whether or not I need to wean of my current meds.
    I am taking a massive dose of Potassium. 210 meq Daily. Along with Hydrocortisone, Fludrocortisone, NatureThroid, Sea Salt,Vit D 6000, Krill Oil 2000, MK-7 100mcg., Magnesium 750 mg., BComplex, Vit C 1000, BiEstro Estrogen, and 1000mcg MethylB-12.
    Since my MD left town on me, last month, it seems that my only recourse would to be to wean off?!
    I live essentially in the middle of nowhere...........one of those fly over states.......with not alot of options when it comes to healthcare. So finding a physician is a task, let alone finding someone who can work on these issues with me.
    So, .................I'm feeling stuck.........Has anyone else been through this? Would anyone have any suggestions for me?
     
  5. TheChosenOne

    TheChosenOne Senior Member

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    I work with no doctor (currently), because I have no money to pay for one (I'm a student) and I'm fine. The most important reason you need a doctor is to run test.
    I see that you are taking 1000 mcg MethylB12. That is an awful lot. Are you able to tolerate this dose? You are also taking a B complex. Does it contain folic acid? This is not always good for everyone.

     
  6. caledonia

    caledonia

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    Cincinnati, OH, USA
    That's a lot of delicate stuff which should be under a doctor's care.

    See if you can find a functional medicine practitioner (traditional doctor who is also versed in alternative medicine).
    https://www.functionalmedicine.org/practitioner_search.aspx?id=117
    I was surprised how many of these were in my area.

    Or maybe a regular GP plus a naturopath.
     

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