Wall Street Journal, November 20, 2012, "As MS Pills Debut, Doctors Prescribe a Dose of Caution" Newest pill, Aubagio, another called BG-12 in the pipeline, join Gilenya which was approved in 2010. Excerpts of interest to ME/CFS: "Reseachers say multiple sclerosis wreaks havoc with a patient's immune system, causing it to damage healthy nerves and the myelin sheaths that wrap around nerve fibers, disrupting signals from the brain. Researchers still don't understand why the immmune system goes haywire. They believe it is a combination of genetic and environmental factors, including exposure to a virus." "It is difficult to find multiple sclerosis treatments that are both effective and safe, experts say, because the understanding of the disease continues to evolve."