Honestly, there seems to be far more "desperation" from the handful of people who, without fail, show up to every single XMRV conversation to smother curiosity and derail the exchange of ideas with heavily value- and bias-laden proclamations. Of course everyone is allowed their opinions and entitled to present whatever arguments and evidence they want, but there is a starkly qualitative difference between those engaged in genuine skepticism and those attempting to ride roughshod over the conversation with their agendas. It can be difficult to distinguish these in one-off instances, but over many iterations a rather clear picture emerges, as evidenced by more and more people following this research catching on to the truly bizarre and reflexive nature of these inevitable attempts to scuttle honest conversation. This constant haranguing and unremitting need to sow doubt, distrust, and confusion seems to be exclusive to XMRV discussions. I also disagree with your claim that XMRV would have been discarded by now if it were any other issue. Off the top of my head, the only other research avenues that I can recall being fully discarded in ME are prior retroviral discoveries. In the world of ME research, it instead seems to be the case that the likelihood of an issue being discarded is positively correlated to its hypothetical explanatory power and inversely correlated to the strength of evidence for discarding it.