This new paper by Morris, Berk, Walder and Maes seems to be an excellent comprehensive review of how viruses, bacteria and fungi might be causing inflammation, and thus ME CFS. The biochemistry is beyond me but Figure 1 seems to sum it all up. In the past few years I have often wondered - 'why do some people with these infections become chronically ill, whereas others do not?' The paper talks about the genetics of ME CFS (see quote below) --how many of us have had the TLR or cytokine genes tested? "The role of functional polymorphisms in TLR or cytokine genes in the genesis and maintenance of such a presentation appears to be a promising avenue for research given that such genetic abnormalities are known to influence an individual’s susceptibility to infection, the severity and duration of the immune response, and the development of chronic illness.."