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New paper: Apobec 3G reduces infectivity of the XMRV

Discussion in 'XMRV Research and Replication Studies' started by RustyJ, Jul 23, 2010.

  1. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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  2. VillageLife

    VillageLife Senior Member

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    this is really amazing!!
  3. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    I am not sure how this extends the previous 2 studies. Regarding above point, I think someone commented that XMRV may still be bypassing A3G in cells that do contain that protein. One other point, are there any other parts of the body that do not contain A3G where XMRV is more likely to find refuge. I guess this information is important for treatment, for targetting persistent reservoirs of XMRV after ARVs have beaten it back to these reservoirs. Can anyone add to this?

    I note that someone has started another thread on this subject, some time after this one. I don't know the protocol in this situation - should they be merged?
  4. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    I had another rare thought. What if this is why many people don't contact XMRV: because A3G kills it off in most tissue before it can get a hold. In other words, some people are lucky and some just ain't. Also could mean that genetics, environmental factors etc play little part in whether the virus takes hold.
  5. Cort

    Cort Phoenix Rising Founder

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    I wondered about that as well? Maybe in the sickest patients APOBEC is not working as well?
  6. natasa778

    natasa778 Senior Member

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    I wonder if any environmental toxins inhibit APOBEC?
  7. Otis

    Otis SeƱor Mumbler

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    An interesting topic for speculation, to be sure.

    Seems like there are some interesting study possibilities here.

    Type of onset may be a consideration with APOBEC effectiveness.
  8. leaves

    leaves Senior Member

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  9. VillageLife

    VillageLife Senior Member

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    Yep I thought this and does it explain why we may have good weeks and bad weeks maybe the APOBEC works better at times.
  10. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    I think it reads that APOBEC is a gatekeeper. Once the virus is in the cell without getting pinned by APOBEC it's there for keeps. So it is unlikely APOBEC would have the sort of impact you are talking about. APOBEC would either stop the virus at its initial contact, or once the virus had a foothold APOBEC would slow down its spread, but not stop it entirely.

    Maybe temporary symptom relief is more due to the relative effectiveness of the immune system and/or stage of concurrent infections.
  11. judderwocky

    judderwocky Senior Member

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    or maybe we have a variant??? they haven't done any studies on variants for APOPEC3 yet in CFS patients have they?

    does anybody know?
  12. judderwocky

    judderwocky Senior Member

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    a good point... and a lot of these defense factors work "in conjunction" with one another....

    it could also be that like they are now discovering with HIV.. you need other viruses to weaken the body before it can take hold....like herpes helps hiv infect the mucosa.... maybe an entero virus or something could be what is weakening our system to let it in... then once it is established... it takes hold and becomes a permanent root cause... the defreitas retrovirus?
  13. RustyJ

    RustyJ Contaminated Cell Line 'RustyJ'

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    Judder, Cort, you may be right. APOBEC may be affected in ME patients. Could it be that everyone has underestimated the role APOBEC has played? Mikovits has only recently suggested there might be 2 types of XMRV - one type in the prostate and one in ME patients. In fact, Cort, you highlighted this in "A different kind of XMRV?" http://www.forums.aboutmecfs.org/con...niello-on-XMRV

    I thought it was important, so I started a new thread on it. http://www.forums.aboutmecfs.org/showthread.php?6526-Two-different-types-of-XMRV-revisited&


  14. JillBohr

    JillBohr Senior Member

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    Very interesting leaves since Judy stated that the only immune marker associated with XMRV is decreased interferon alpha.

    http://www.forums.aboutmecfs.org/sh...Mikovits-IACFS-ME-Newsletter-Apr-2010-Q-amp-A

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