Hi. This is my first post on this thread. I've had major depression (and probably CFS) for over 30 years. 2.5 years ago my doc discontinued my hydrocodone (after getting me addicted to it) and I crashed and burned. The cold turkey was nothing compared to the after effects. I was bed ridden for 4 months, could hardly function. Major brain fog, memory problems, speech difficulties, deep, dark, sucidial depression, intrusive thoughts, and racing mind. I think it may have to do with causing a intolerance to Valium. I had all the symptoms of Valium withdrawal. I've been slowly micro tapering V from 15 mg to 3. This has taken me 2 years. I feel better but no way like my pre crash days. I'm afraid the crash was caused by a glutamate storm and I have neuronal damage. If anyone has had a similar experience or could recommend supplements, etc, I'd be grateful.