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New KDM, Lombardi research--HERV

Discussion in 'Latest ME/CFS Research' started by Sushi, Feb 19, 2013.

  1. Daffodil

    Daffodil Senior Member

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    i still dont quite understand the outbreaks and unmistakable instances of transmission of CFS.....one might say that these people in one area or one family all had similar gut issues / immune activity / inflammation due to some environmental cause and then getting an acute infection (or whatever) somehow made them all get CFS because it further activated HERV's??

    this part seems a little weird. i know there have some rare outbreaks of MS and other autoimmune diseases, but CFS outbreaks weren't all THAT rare and families with mulitple ill members isnt that rare, either. so how is CFS different from lupus or MS?
     
  2. Gijs

    Gijs Senior Member

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    i think this finding is the result of the autonomic overdrive i.e. abnormal stressrespons started by (nor) adrenaline. This finding does not fit in a causal model.
     
  3. MeSci

    MeSci ME/CFS since 1995; activity level 6

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    A possibility is that what autoimmune illness you get depends on environmental, and possibly genetic, factors. Thus re environmental factors, all may get leaky gut, but depending on diet, medications, chemicals, etc., that enter the gut, different substances will pass through the leaky gut wall into the bloodstream and therefore trigger the production of different antibodies, and then autoantibodies to body substances similar to the foreign ones, and as they are different antibodies they attack different body systems.

    I haven't explored this through research, but it just seems logical and could explain the differences. Genetic factors could include predispositions to leaky gut or to sensitivity to certain substances (e.g. gluten).
     
  4. lansbergen

    lansbergen Senior Member

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    I disagree
     
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  5. serg1942

    serg1942 Senior Member

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    *** Hi guido,

    "@Sergio: Really? What exactly does it explain? I am totally accepting that the presence of strange DNA leads to disturbances once molecules come free, but that's the consequence of an inflammatory disease, not the cause, and it doesn't necessarily lead to medical complaints either."

    ***the HERV is part of our own genome, and it may cause inflammation by the process explained in the paper (expressing proteins that will act as superagents, causing disruption in the normal process of antigen pressentation), and I think it may be very plausible that it explains the symptoms as well.

    *** Hi Valentinj,

    "That does seem like something interesting to look for ... but couldn't healthy people have the proteins without the immune reaction to them?"

    *** Yes, they do, it's explained in the paper.

    *** Well, I'm going to write to some specialists, b/c I would like to solve my doubts about the exact proposed mechanism. If I have success in doing this, I'll report it here. (and please, if someone can try to answer me, go ahead! )

    Saluditos,
    Sergio
     
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  6. Gijs

    Gijs Senior Member

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    In addition, I think that researchers like Lombardi and the WPI after the XMRV debacle not be taken seriously. I hope for those researchers that at least the research is carried out professionally this time. This model (HERV) does not explain the symptoms and findings by other researchers. How and what is infected in de nervous system that explains the chronic overstimulated autonomic part or the abnormal stressrespons by (HERV). It makes no sense. I am not so optimistic. It is one of the many abnormalities.
     
  7. lansbergen

    lansbergen Senior Member

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    I disagree and will not waste my time and energy on a yes no dispute.
     
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  8. Guido den Broeder

    Guido den Broeder *****

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    My guess is that it's even normal, rather than abnormal, and always happens when these cells are activated. But I'd welcome more research. We are still missing a factor that explains why some people get ME and others don't, especially in outbreaks.
     
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  9. serg1942

    serg1942 Senior Member

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    Well, it's not normal, when it's not found in healthy controls, and it's been found not only in CFS, but in many other autoimmune disorders... (I mean the reactivity of proteins transcribed by HERVs)...

    S.
     
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  10. Daffodil

    Daffodil Senior Member

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    i'm concerned as to why they found this in only 8 out of 12 CFS patients and not all of them.

    its really neat that PDC problems can result in massive cytokine production and it is also very interesting that PCD's play a big part in activating NK cells....or something...

    this is SO over my head lol
     
  11. Guido den Broeder

    Guido den Broeder *****

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    Possibly the remaining 4 are post-HHV5 or 6 and not post-EBV.

    Or their inflammation hasn't reached the gut, or they don't have ME at all, or they don't have this specific HERV.
     
  12. Firestormm

    Firestormm Guest

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