I suffer from chronic, worsening depression which feels physical in nature and is now failing to respond to SSRIs at therapeutic doses. I live in NJ and have gone to see Dr. Neubrander in order to get the functional methylation panel done in Holland. I'm awaiting results. In the meantime, the doctor gave me an Rx for methyl B12 shots at a daily dose of 1.25 mg per day, subQ, since he said that we all need B12. Fair enough.I started them on Saturday and spent the weekend in bed feeling drowsy, but not sleeping. Since then, I've noticed no change in energy or mood. Yesterday I felt a bit better, but today the crushing depression is back. Complicating things is my weaning off Cytomel and Armour Thyroid, that I was taking for depression and because I have a high RT3/low free T3 problem and have had for a few years. I've been off 25 mcg of Cytomel now for 10 days, Armour for 2 weeks, though was still depressed while on them. I came off as I don't seem to have the adrenal function to support the increase in energy requirements and I also want to go up a level in working back to find causes of my issues. I don't want to take full replacement doses of Cortef if I can possibly avoid it. Is it normal to feel no benefit from the B12 in the beginning? I'm beginning to think I need just much, much more since I've felt depressed for about 8 years now. The only times I've felt normal are when I take Vyvanse and Adderall, but the crashes and insomnia prevent me from taking stimulants all the time. I don't take any other vitamins or supplements right now. I do take Buhner herbs for Lyme disease. Was on antibiotics for 2 years, and wonder if that might have caused malabsorption issues. I'm used to pushing through things and am lucky enough to still be able to work and jog, so better off than many on this board. But I'm so miserable....any advice?