New exome testing $400

[RogerBlack]

Anyone willing to share their exome sequencing for hypothesis generation? Please PM me if you've got yours and are willing to share.

https://en.wikipedia.org/wiki/Personal_Genome_Project interested me.

I have no particular interest in mine remaining private.

This is not currently enrolling patients in the UK though.

 

[Snow Leopard]

The whole genome may be available for £114/$200Au by the end of the year
https://www.genomix.co/get-your-genome-sequenced

I signed up to their list a while back and haven't heard anything yet.

 

[Jenny TipsforME]

@RogerBlack it looks like UK enrolment is only temporarily paused http://www.personalgenomes.org/uk/sign-up (you get your info for free but it is publicly available online for researchers to use).

I've thought about this on and off and each time I feel positive about it I find a reason to be cautious. I like the idea of sort of donating DNA info to science but I think you have to do it assuming you could be identified (you provide other information about yourself too). It's hard to know how this information could be misused in the future and potentially could cause prejudice for relatives too.

Yesterday when I was looking at this stuff I came across people angry at really basic email list errors, which doesn't inspire confidence.

My financial situation isn't as dire as it used to be, so I feel with prices coming down it is better to pay for some privacy.

 

[RogerBlack]

@RogerBlack it looks like UK enrolment is only temporarily paused http://www.personalgenomes.org/uk/sign-up (you get your info for free but it is publicly available online for researchers to use).

"temporarily paused" - since at least July 2014.

 

[TrixieStix]

Hmm so Genos has an error rate of 0.5% which means a 1 in 200 error rate in reporting of SNPs. So even if you discover you have a variant that could have serious implications you still don't know if it's actually been read/reported correctly.

Plus Genos doesn't give you all your exome information, but instead only gives you data about the things in your exome that are different from the reference data. "This doesn’t mean that it is everything that is heterozygous or homozygous for the minor allele (a bad assumption on my part), but it is just everything that is different from a reference file."

I got this information from the following review.

https://www.geneticlifehacks.com/review-of-genos-whole-exome-sequencing/

 

[Valentijn]

Plus Genos doesn't give you all your exome information, but instead only gives you data about the things in your exome that are different from the reference data.

The raw data is available, it's just difficult to access, since processing and accessing genetic data requires certain tools and programs. I'm not sure why the blogger thinks they could do something meaningful by scrolling through a list of 50 million SNPs. Most programs can't handle that much data even as text, and the files probably contain a lot of additional information.

But they should still be able to look up specific SNPs via their website, from what I understand.

 

[Jenny TipsforME]

@Valentijn have you seen this?

https://www.dantelabs.com/collections/our-tests/products/whole-genome-sequencing

Currently WHOLE GENOME testing for €599

Does this seem legit?

 

[Valentijn]

https://www.dantelabs.com/collections/our-tests/products/whole-genome-sequencing

Currently WHOLE GENOME testing for €599

Does this seem legit?

Honestly, a lot of things are making me uneasy about that one. It's not a good name (Dante being associated with hell), the price doesn't seem realistic for WGS at this point, the example of risk data is frivolous, and their tagline "Never Worry Again" is creepy as hell.

Their logo is an altered rip-off of 23andMe's logo. The box they show also looks like a rip-off of the 23andMe box, with text definitely copy-and-pasted on the inner lid (not part of a genuine photo). There's also weird colors (orange, pink, and purple) visible around the edges of their image of the open box if you zoom in, which shouldn't be in those places based on their images of the closed box. One of their lab photos is a stock image and the other is taken from the website of a university in Canada. So I'm not sure if anything they are showing exists at all.

I wouldn't send them money or any information.

 

[Jenny TipsforME]

@Valentijn i hadn't thought of name connotations but Dante is not a clever business name... I put 'creepy as hell' through fakespot and it doesn't come out well (graded F compared to an A for 23andme)
https://www.fakespot.com/product/da...ysis-whole-genome-sequencing-wgs-30x-coverage

Probably in the Too Good to be True category! We are expecting genetic testing to get cheap though, too soon for this price?