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New evidence of how gut microbes affect Inflammatory Bowel Disease

Discussion in 'Other Health News and Research' started by AndyPR, Jan 25, 2017.

  1. AndyPR

    AndyPR Senior Member

    http://www.ifr.ac.uk/news/latest-ne...-microbes-affect-inflammatory-bowel-disease/#

    Study the article is referencing http://rsob.royalsocietypublishing.org/content/7/1/160155
     
  2. ash0787

    ash0787 Senior Member

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    Anyone know much about Chrons disease ? that was another one that seemed to be little understood by scientists even though it causes obvious physical changes, perhaps that is what this paper is talking about
     
  3. M Paine

    M Paine Senior Member

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    Auckland, New Zealand
    A friend of mine has Crohn's, and asked a while back if I could look into it for her. My understanding is that Crohn's disease involves an autoimmune component. One area of promising research is directed at MAP infection (Mycobacterium Avium Paratuberculosis) as a possible cause in some patients.
     
  4. Murph

    Murph :)

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    This is some of the most specific work I've seen on the role of bacterial metabolites. Seems like we're coming a long way on the understanding of leaky gut!

    As recently as a few years ago the evidence for the leaky gut hypothesis was not strong enough for mainstream medicine to believe in it and it was considered fringe. Now we're seeing progress.

    I'm fairly sure gut permeability is important for many me/cfs sufferers (digestive and body-wide symptoms go hand-in-hand for me). Things leaking into the bloodstream from the gut could be exactly what causes the immune system to decide hypometabolic/sickness responses are the body's best option.

    As for direct application, if you're wondering if what works in the mouse epithelium will work in yours too, B.breve is easily available for purchase. I'd be interested to hear if anyone's already taking it.
     
    ljimbo423, bertiedog and ScottTriGuy like this.
  5. M Paine

    M Paine Senior Member

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    Auckland, New Zealand
    I tend to agree, LPS and other microbial products entering the bloodstream is a simple and straight forward mechanism for innate and adaptive immune activation. It doesn't explain everything, but it's certainly worth exploring in more detail.
     
    ScottTriGuy likes this.

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