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New drug-resistant gut bacteria reported

Discussion in 'Other Health News and Research' started by richvank, Sep 14, 2010.

  1. richvank

    richvank Senior Member

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    Hi, all.

    The news media today are carrying
    stories about newly-discovered drug-resistant gut bacteria that may
    have originated in India. A gene called NDM-1 is being exchanged
    between different species of bacteria, making them resistant to most
    antibiotics. With all the gut problems PWMEs/PWCs already have, this
    is not good news. I think this really emphasizes the importance of
    considering non-pharmaceutical antimicrobials.

    Best regards,

    Rich


    Lancet Infect Dis. 2010 Sep;10(9):597-602. Epub 2010 Aug 10.
    Emergence of a new antibiotic resistance mechanism in India, Pakistan,
    and the UK: a molecular, biological, and epidemiological study.

    Kumarasamy KK, Toleman MA, Walsh TR, Bagaria J, Butt F, Balakrishnan
    R, Chaudhary U, Doumith M, Giske CG, Irfan S, Krishnan P, Kumar AV,
    Maharjan S, Mushtaq S, Noorie T, Paterson DL, Pearson A, Perry C, Pike
    R, Rao B, Ray U, Sarma JB, Sharma M, Sheridan E, Thirunarayan MA,
    Turton J, Upadhyay S, Warner M, Welfare W, Livermore DM, Woodford N.

    Department of Microbiology, Dr ALM PG IBMS, University of Madras,
    Chennai, India.
    Abstract

    BACKGROUND: Gram-negative Enterobacteriaceae with resistance to
    carbapenem conferred by New Delhi metallo-beta-lactamase 1 (NDM-1) are
    potentially a major global health problem. We investigated the
    prevalence of NDM-1, in multidrug-resistant Enterobacteriaceae in
    India, Pakistan, and the UK.

    METHODS: Enterobacteriaceae isolates were studied from two major
    centres in India--Chennai (south India), Haryana (north India)--and
    those referred to the UK's national reference laboratory. Antibiotic
    susceptibilities were assessed, and the presence of the carbapenem
    resistance gene bla(NDM-1) was established by PCR. Isolates were typed
    by pulsed-field gel electrophoresis of XbaI-restricted genomic DNA.
    Plasmids were analysed by S1 nuclease digestion and PCR typing. Case
    data for UK patients were reviewed for evidence of travel and recent
    admission to hospitals in India or Pakistan.

    FINDINGS: We identified 44 isolates with NDM-1 in Chennai, 26 in
    Haryana, 37 in the UK, and 73 in other sites in India and Pakistan.
    NDM-1 was mostly found among Escherichia coli (36) and Klebsiella
    pneumoniae (111), which were highly resistant to all antibiotics
    except to tigecycline and colistin. K pneumoniae isolates from Haryana
    were clonal but NDM-1 producers from the UK and Chennai were clonally
    diverse. Most isolates carried the NDM-1 gene on plasmids: those from
    UK and Chennai were readily transferable whereas those from Haryana
    were not conjugative. Many of the UK NDM-1 positive patients had
    travelled to India or Pakistan within the past year, or had links with
    these countries.

    INTERPRETATION: The potential of NDM-1 to be a worldwide public health
    problem is great, and co-ordinated international surveillance is
    needed.

    PMID: 20705517 [PubMed - in process]
     
  2. leela

    leela Slow But Hopeful

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    Couchland, USA
    Thanks, Rich, this is useful since PWME/PWCs do indeed have relentless gut issues.
    (On a side note I am surprised how often that is left out, or minimized, on descriptions of the symptoms of this illness.)

    Anyhow, I have just emailed the above to a friend of mine who is an Ayurvedic practitioner and travels to India yearly. She replied that thinks she contracted one of the above last year, and reports that in fact antibiotics did nothing, but Goldenseal did the trick.

    For those not allergic to ragweed, this could be a good thing to have in mind.
     
  3. MDL

    MDL

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    Rich,

    Thanks for posting this. It is the sort of thing that should be looked at more carefully.
    MDL
     

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