The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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New Coyne blog: "An open letter to the Cochrane Collaboration"

Discussion in 'General ME/CFS News' started by worldbackwards, Mar 6, 2016.

  1. worldbackwards

    worldbackwards A unique snowflake

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    Marky90, green_monster, Yogi and 13 others like this.
  2. Kati

    Kati Patient in training

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    James attacks the cochrane review concerning evidence over graded exercise therapy for ME/cfs.

     
  3. Sasha

    Sasha Fine, thank you

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    It's a good thing - tackling PACE on lots of fronts looks like an effective strategy. Sooner or later, one of them will pay off and in the meantime, it will raise awareness about PACE among the wider community of scientists.
     
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  4. Denise

    Denise Senior Member

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    ( @Sasha posted Clark Ellis' post about AYME's statement.)
    AYME's statement references the Cochrane review mentioned in Coyne's new post.
     
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  5. BurnA

    BurnA Senior Member

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    Can someone explain to me what exactly this Cochrane review was ?
    And why are White, Sharpe and Chalders names on it ?
    Thanks, I'm confused.
     
  6. Mrs Sowester

    Mrs Sowester BRING BACK KINA

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  7. BurnA

    BurnA Senior Member

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  8. Mrs Sowester

    Mrs Sowester BRING BACK KINA

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    I assumed it is the same one, but might be wrong...hopefully someone who knows will chip in
     
  9. Denise

    Denise Senior Member

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    Coyne quotes:
    Larun L, Odgaard-Jensen J, Brurberg KG, Chalder T, Dybwad M, Moss-Morris RE, Sharpe M, Wallman K, Wearden A, White PD, Glasziou PP. Exercise therapy for chronic fatigue syndrome (individual patient data) (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD011040. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011040/abstract
    (which as you can see has (among others) Chalder, Sharpe, White as authors of a review on exercise therapy for "cfs")
     
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  10. Stewart

    Stewart Senior Member

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    It is - Coyne has linked to the protocol for the review (which is what White, Sharpe and Chalder were involved in writing) rather than the finished review. As near as I understand it, his complaint is that this is the next best thing to marking your own homework - except rather than mark it yourself you get a bunch of your friends to mark it in line with the criteria you've just given them.

    So you can tell them which sorts of studies they should include in the review, which ones they should ignore, what data they should consider important and unimportant - and what criteria they should use when they inevitably decide that the PACE trial results are completely sound. And then you use the fact that your friends have given it a clean bill of health as evidence to prove that you're prepared to release the data to 'independent' researchers.
     
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  11. Sasha

    Sasha Fine, thank you

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    Is it actually the same review? The protocol is for an individual-patient-data review (where the review authors ask the study authors for their raw data) but the one with the results looks like it was based on published group results from each paper.
     
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  12. Sasha

    Sasha Fine, thank you

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    Answered my own question: no, they're different. The one with results is based on the published literature and it says:

     
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  13. Yogi

    Yogi Senior Member

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