When I started on LDN a few months ago I realized I had to take it in the morning because it kept me up all night. When I take it in the morning I feel pretty good. I recently got a refill from a different source because the compounding pharmacy my doc uses is outrageously expensive and she was not comfortable RX'ing it out of state so I could get it at Skip's. I haven't slept in 3 nights, each night getting worse. I realized it must be the LDN at 3 a.m. this morning when I was still up. I took one this at 7:30 a.m. morning so I could pay attention to how I felt and I'm feeling really jittery and not in a good way. What could be different in this one that is doing it to me? I know they used the Avicel as the binder. I even changed the capsules to see if that was the problem. That doesn't seem to make a difference. What could this be? I'd like some ideas before I contact the pharmacy about this. Thanks I found out the LDN I can take sources their naltrexone from Medisca. The one I can't take is from PCCA. I hate when pharmacists tell you you can't be having a reaction to a medication! I am, so WTF?