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New Class of Potential Drugs Inhibits Inflammation in Brain

Discussion in 'Other Health News and Research' started by Bob, Feb 15, 2012.

  1. Bob

    Bob

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    England (south coast)
    Article in Science Daily...

    New Class of Potential Drugs Inhibits Inflammation in Brain
    http://www.sciencedaily.com/releases/2012/02/120214122031.htm


    Extracts from article:

    Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases.

    "EP2 is involved in many disease processes where inflammation is showing up in the nervous system, such as epilepsy, stroke and neurodegenerative diseases,"

    EP2 blockers could find uses in other diseases with a prominent inflammatory component such as cancer and inflammatory bowel disease."
     
  2. alex3619

    alex3619 Senior Member

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    Hi Bob, I have been pushing this line of research since 1993, since it was pioneered here in Australia by my CFS doc at that time. He was shut down and could not find funding. My protocol has always aimed at reducing PGE2 and related eicosanoids. The body gets a burst of these things (series 2 inflammatory eicosanoids) when drinking alcohol, its very neurotoxic. They in turn induce oxidative stress and other inflammatory cascades. We also get a burst if we eat meat fat or any other concentrated source of arachidonic acid. A small amount is good. A bigger amount is bad. A lot at once is very very bad.

    This current approach is focussing on post-arachidonic acid enzymes as inhibitory targets. This is like super-vioxx but avoiding many of the pathways that vioxx shut down, so side effects should be significantly reduced over COX2 inhibitors. It will have to be very carefully tested though, as COX2 inhibitors are very dangerous.

    Bye, Alex
     
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  3. xrayspex

    xrayspex Senior Member

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    Alex, what is your protocol to reduce them?
     
  4. Enid

    Enid Senior Member

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    Very interesting - thanks Bob. Couldn't make out (and Docs) whether CNS infection or inflammation as ME progressed to it's worst (encephalitis). Note alex's caution though.
     
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  5. adreno

    adreno PR activist

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  6. adreno

    adreno PR activist

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    Why are Cox2 inhibitors dangerous?
     

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