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New class of antibiotics discovered by chemists

Discussion in 'Other Health News and Research' started by Ecoclimber, Mar 7, 2014.

  1. Ecoclimber

    Ecoclimber Senior Member

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    This is good news!


    University of Notre Dame. "New class of antibiotics discovered by chemists." ScienceDaily.

    ScienceDaily
    Date: March 7, 2014
    Source: University of Notre Dame

    Summary:
    A new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus and other drug-resistant bacteria that threaten public health has been discovered by a team of chemists. The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

    A team of University of Notre Dame researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. Their research is published in the Journal of the American Chemical Society in an article titled "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity."

    The new class, called oxadiazoles, was discovered in silico (by computer) screening and has shown promise in the treatment of MRSA in mouse models of infection. Researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs. The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.

    MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.

    The researchers have been seeking a solution to MRSA for years. "Professor Mobashery has been working on the mechanisms of resistance in MRSA for a very long time," Chang said. "As we understand what the mechanisms are, we can devise strategies to develop compounds against MRSA."

    "Mayland Chang and Shahriar Mobashery's discovery of a class of compounds that combat drug resistant bacteria such as MRSA could save thousands of lives around the world. We are grateful for their leadership and persistence in fighting drug resistance," said Greg Crawford, dean of the College of Science at the University of Notre Dame.

    Journal Reference:
    1. Peter I. O’Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lastochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery, Mayland Chang. Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity. Journal of the American Chemical Society, 2014; 136 (9): 3664 DOI: 10.1021/ja500053x
     
    Valentijn, heapsreal, Ema and 5 others like this.
  2. Bob

    Bob

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    England (south coast)
    "in silico"
    Not heard that term before!
     
    Valentijn and merylg like this.
  3. Martial

    Martial Senior Member

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    Ventura, CA
    My friend almost died of MRSA infection from putting on a dirty foot ball sock, it started in his calf and almost stopped his heart at one point.. Was in the hospital for months! Sadly he passed away recently from a car accident though.. R.I.P. Nick.

    Anyways great post thanks for sharing!
     
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    About one in three have MRSA now, and up to half of all medical professionals. A new antibiotic is greatly needed. I am an MRSA carrier, and no matter what we do its slowly spreading through the population. To be clear though, MRSA is not a problem on the skin, its only when it starts infecting deeper tissue that it is a problem. Its also not worse than staph aureus except in one respect: there are almost no treatments. Everybody has staph aureus.
     
    Valentijn likes this.
  5. Wendi C

    Wendi C

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    New Mexico
    My husband almost died of MRSA years ago. The antibiotics given gave him a lifetime of side-effects that he fights weekly (vancomycin). The recurrences happened for a year or two after but thankfully a really smart PA had him try taking 2 different abx; one that he wasn't resistant to and one he was. It worked thankfully and were mild abx that caused little side effects.

    No more recurrences in over 5 years thankfully, but this is good news! AND HE CAUGHT HIS IN HOSPITAL HAVING A ROUTINE COLONOSCOPY. Makes me so angry when I think all we went through could have been avoided. :bang-head:
     

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