Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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New blog from Professor Coyne on the Cochrane Collaboration Review

Discussion in 'General ME/CFS News' started by Daisymay, Apr 21, 2016.

  1. Daisymay

    Daisymay Senior Member

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    "My response to an invitation to improve the Cochrane Collaboration by challenging its policies"

    April 21, 2016James C Coyne

    https://jcoynester.wordpress.com/20...ne-collaboration-by-challenging-its-policies/

    or http://tinyurl.com/hl6jv4r

    Excerpt:

    "The declared conflicts of interest of the PACE investigators in The Lancet paper constitute a high risk of bias. I am familiar with this issue because our article which won the Bill Silverman Award highlighted the importance of authors’ conflicts of interest being associated with exaggerated estimates of efficacy. The award to us was premised on our article having elicited a change in Cochrane policy. My co-author Lisa Bero wrote an excellent follow-up editorial for Cochrane on this topic.

    This is a big deal and action is needed

    Note that this 2016 systematic review has only three new studies considered that were not included in the 2004 review. So, the misrepresentations and incorrect calculation of effect sizes for two added trials– PACE and FINE – are decisive.

    As it stands, the Larun et al Cochrane Review is an unreliable summary of the literature concerning exercise for “chronic fatigue syndrome.” Policymakers, clinicians, and patients should be warned. It serves the interests of politicians and re-insurance companies–and declared and undeclared interest of the PACE investigators.

    I would recommend that Dr. Lillebeth Larun recuse herself from further commentary on the 2016 systematic review until complaints about her conflicts of interest and unreproducibility of the review are resolved. The Cochrane should also publish an Expression of Concern about the review, detailing the issues that have been identified here.

    Stay tuned for a future blog post concerning the need to move “chronic fatigue syndrome” out of the Cochrane Common Mental Disorders group."
     
    Woolie, sue la-la, Sean and 15 others like this.
  2. Esther12

    Esther12 Senior Member

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    With FINE changing from bimodal to likert, the researchers had claimed that this led to them being able to move from a null result to a significant reduction in fatigue for Pragmatic Rehabilitation. I think that the Cochrane analysis of their data found that this was not true though. I never really dug into this, but it looked like the FINE claim was an error. It had only ever been published as a part of a BMJ rapid response.
     
    Woolie, Valentijn, Sean and 1 other person like this.

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