My sublingual Galavits arrived 3 days ago. This morning I took the third dose. It stopped my ibs diarrhea after second day. For the first time in last ten years, I didn't take Loperamide to reduce bowel movements since two days ago. I haven't felt any difference regarding other ME symptoms but it is too early. Average response time for Rituximab was 3 months if I remember correctly. I am hopeful. The last two days prior to starting Galavit was very exhausting for me including a 10 hour coach travel. I was in PEM when I started Galavit. I am still in PEM but it is slightly milder than the previous ones. Galavit might be alleviating symptoms but it is too early to draw conclusions.