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'New' antiinflammatory antioxidant drug on the market

Discussion in 'Other Health News and Research' started by natasa778, May 10, 2014.

  1. natasa778

    natasa778 Senior Member

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    I have been looking into things that could potentially regulate Nrf2 activity (see why) and came across this 'novel' drug. It has been used in Russia for decades, now it seems it has been repackaged and in search of new markets.

    The mechanisms of action sound 'too good to be true' :) I haven't seen it discussed or suggested as having potential for ME. Any docs use it? (on the other hand it is not clear if it is available at all, or would be, outside Eastern and Central Europe?)

    http://www.bachpharma.com/origins.php

     
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  2. natasa778

    natasa778 Senior Member

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    link to countries and approvals/indications

    http://www.bachpharma.com/pipeline.php

    Hungary has already approved it has immuno-modulatory and anti-inflammatory … also available in Germany in Switzerland

    Second table shows current clinical trials, including in the US — interesting list!!
     
  3. maryb

    maryb iherb code TAK122

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    Wow - looks fantastic now if it does what it says who knows how much it could help us.
     
  4. GhostGum

    GhostGum Senior Member

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    Any idea what it was before being repackaged? Since it may have been around in the Soviet era figured there maybe a slight chance it could have fallen into the supplement category or that it may have been in the open market and some company has just patented it and claimed it. Regardless I am guessing they have full rights now.

    Does sound a little too good to be true, given the claims it is odd it has been dormant.

    Edit: Sorry should have just checked the page, Monosodium Luminol.
     
  5. Ema

    Ema Senior Member

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  6. natasa778

    natasa778 Senior Member

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    according to this page (no idea if true info)

    In Russia, Galavit has been prescribed to treat a wide range of chronic inflammatory diseases. These include illnesses with an autoimmune component—such as Crohn's disease, liver diseases, rheumatoid arthritis, ulcers and ulcerative colitis.

    Doctors have also used Galavit to treat immune deficiencies arising as side effects of radiation and chemotherapy.
    You should know that Galavit suffered some bad press related to its use as a cancer treatment in a clinic in Bad Karlshafen, Germany. In the summer of 2000, some doctors there declared that the drug could CURE cancer. Desperate cancer patients came from around the globe in hopes of experiencing miracle healing from this Russian wonder drug. The clinic charged upward of $13,000 for treatments valued at less than $500! (To be fair, I'm not sure that practice differs much from what we see in conventional medicine.)Sadly, the inflated promises rang hollow as all of the patients eventually died. Three people who ran the clinic were sentenced to serve three to seven years in jail for making fraudulent claims about the drug.

    But despite this bungled attempt to profit from the misfortunes of others, many well-intentioned researchers still believed in the drug's potential to help fight disease—including Bach Pharma.
    When they acquired rights to the drug,
    they renamed it MSL (monosodium luminol) and began a series of laboratory studies to validate research previously started in Russia and Germany.


    the original formulation is still sold as Galavit in Russia in few other counties it seems but rx (intramusc injections and rectal supps) only?
     
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  7. natasa778

    natasa778 Senior Member

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    http://www.pharmplanet.com.ua/en/produkty-galavit--poroshok-instukciya/

    Similar with suppositories http://www.pharmplanet.com.ua/en/produkty-galavit--suppozitorii-rektalnye-instrukciya/
     
  8. Martial

    Martial Senior Member

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    Shut up and take my money!

    Has their been any studies of side effect profiles or adverse reactions though, it also claims it has no interactions with other drugs?
     
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  9. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I think i have seen it around but have looked into it much. there seems to be several russian type products that work in a similar way, immunofan thye say also works as an antioxidant also while also improves immune function, its on my to do list of things to try.

    Heres galavit in ampoule form, no info on frequency of treatment etc though?
    http://pharmashipping.net/Immune-system/Galavit-injections.
     
  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    just read through some info and it appears to be administered 3 days apart for a total of 10 to 20 injections. This seems similar to other immune mods i have read and similar to cycloferon,

    http://www.ariplex.com/ama/galavit/texte/en/1002.html

    Description.
    Galavit phthalhydrosid salt, clear pulver of white or slightly yellow color, provided in bottles, each bottle contains 100 mg of galavit to prepare a solution by 1-2 ml sterile distilled water, ex temporal, for intramuscular administration.


    Action.
    Galavit id quickly and completely absorbed at the site of administration and rapidly (in 30-60 min.) broken down to its basic compounds, that have no any biological activities, and eliminates from kidney prime rally the effects stay at 6-8 hours.
    The preparation has anti-inflammatory and immunoregulatory effects, leads to inactivation of free radicals and peroxides and inhibit hyper production of IL-1, IL-6 and TNF by macrophages. The pharmacological impact of galavit is based on the achievement of two effects: shot-lived and reversible (6-8 hours) inhibition of hyper activated macrophage's function (production of IL-1, IL-6, FNO, free radiators, peroxides and other inflammatory mediators), and normalization of antigen presenting and phagocyte capacities of macrophages. At the same time galavit is able to produce the elevation of hidden capacities of the neutrophils to kill and eliminate intracellular bacteria. Galavit does not change the normal function of phagocytes.
    The effect of the preparation begins to develop during first 2-3 hours and continues at least for 7 days. During the first phase of action (6-8 hours) the detoxity and anti-inflammatory effect becomes apparent and the organism's antioxidant defense is increased, which leads to normalization of lipid oxidation, and the autoimmune reaction decrease.
    During next 2-3 and up to 7 days after galavit administration phagocytosis of neutrophils increases and can be noticed the reconstruction of broken cellular and humoral immunity by stimulation of T- and B-lymphocytes cooperation. At the same period of time galavit restorates the helper/suppressor ratio and specific antibacterial IgM, IgG and IgA antibodies.
    The administration of the preparation leads to NO, N02, N03 increase and activation of c-GMF-sintetase production in tissues, which display in physiologic correction of vessel's spasm. Galavit also stimulates the production of plasminogen activator by endothelial cells and prevent thrombogenesis.

    Indication.
    Galavit is the drug of choice in the pathogenic treatment of acute and chronic infections and inflammatory diseases, including those with intoxication and diarrheas diseases, opportunistic infection, urogenital infections, autoimmune and allergic inflammatory disorders, traumatic and surgical complications of blood stream, meninges, heart, lung, joints, liver and pancreas, kidneys, complicated by septic and/or pyemic microorganism specific antibacterial and antituberculosis therapy, radiation, immunodepressive and corticosteroid therapy.

    Contraindication.
    Pregnancy, idiosyncrasy

    Precaution.
    Using at the same time any other immunostimulators or biostimulators should be avoided.


    Adverse reaction.
    Sometimes a slight activation of sexual potent ion can be noticed.

    Administration and dosage.
    Galavit is used as the solution of 100 mg in sterile distilled water pro injectionibus. In most of cases it is by 100 mg per day in one injection, it might be given in 24-48-72 hours usually from 10 to 20 in number for course. In accordance to etiology, length, complication, relapse etc. Of disease the course of injections can be repeated in 1-6 months.

    Acute intestinal infections.
    First dose has to be 200 mg, then - 100 mg, 2-3 times per day. Usually, 2-3 injections are enough.

    Chronic and opportunistic infections.
    The daily dose is 100 mg in 24-72 hours. Total number 10-20 injections.



    Immunodeficiency, trauma, surgery complications.
    100 mg per day during 5 days, then - 100 mg per day in 48-72 hours up to 20-25 in number.


    Immunocorrection in oncological patients (cancer, melanoma, sarcoma, etc.), subjected to complex radical therapy, incl. surgery, chemotherapy and radiation therapy
    100 mg per day during 5 days (in 24 hours), then 100 mg per day in 72 hours. 20-25 doses total.

    Anglopathey (incl. diabetic) 100 mg per day during 5-10 days, then in 48-72 hours up to 20-25 in total

    Ulcer of stomach, ulcerous colitis, cutaneaus ulcers etc.
    Intramuscular injections of 100-200 mg ofgalavit 1-2 times per day, 10-20 in total.
    It is possible to administrate paraulceral injections in 100-200 mg ofgalavit once in 48-96 hours, 3-4 injections in total.

    Autoimmune syndromes.
    100 mg per day during 5 days, then - 100 mg per day in 48-72 hours up to 20-25 in number.

    Reactive arthritis, incl. rheumatisms.
    Intramuscular injections of 100 mg daily, in a day or once in 3 days, 10-20 total. If inflammation is severe, first 2-3 injections shall to be of 200-300 mg, then 100 mg, 10-20 total.


    Storage.
    Galavit should be stored away from heat and light, up to 2 years. The preparation shall not be used in solution, if prepared not ex temporal pro injections and not after the date stamped on the label.
     
  11. barbc56

    barbc56 Senior Member

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    :thumbdown::thumbdown:

    Someone had to ask.

    Barb

    ETA Do not google this term. Don't even think about it. Anyone know of a way to find the scientific definition?

    Carry on!:)
     
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  12. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    pitching the tent ;)
     
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  13. Ema

    Ema Senior Member

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    So does this work kind of opposite of GcMAF?

    I thought that increased the action of macrophages, whereas this Galavit seems to indicate that the macrophages are already hyper activated?
     
  14. melihtas

    melihtas

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    www.piluli.ru/product/Galavit (Google translated)

    On this Russian site Galavit prices:

    Galavit tablets 25 mg, 20 pcs. (Sublingual) Price 280 rubles = 8 USD

    Galavit vials 50 mg, 5 pcs. (IM) Price 457 rubles = 13 USD

    Galavit rectal suppositories 100 mg, 10 pcs. Price 714 rubles = 20 USD

    They don't have international delivery, I just posted for information.
     
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  15. melihtas

    melihtas

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    I thought there would be more interest for this drug.

    I live in Turkey and I have a relative who lives in Kazan Russia. I told him about the drug and he bought 4 packs of sublingual Galavit for me. He is waiting someone to travel to Istanbul to send the drugs. Posting them is not an option because our customs confiscates any drug and supplement.

    I will get the drugs in a week or so and I will share my experience with Galavit in this thread. If I experience significant improvement after a month, I will open a new thread with detailed information.
     
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  16. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I think with immune mods, they are something we have to keep taking and may take time to see obvious effects as it takes time to lower infectious load. Also possible worse before you get better scenario. But then again some have anti inflammatory effects that can help quickly??
     
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  17. melihtas

    melihtas

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    You are right, there will be short term effects and long term effects. For short term I expect it to help with my gut problems. Galavit is used for inflammatory bowel diseases. I have ibs with diarrhea and I take 3-4 Loperamide(Immodium) tablets every day to reduce my bowel movements. Even if Galavit helps me only with gut problems, my quality of life will be dramatically improved.
     
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  18. melihtas

    melihtas

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    I found some information about all Russian immunomodulators.
    http://www.biomedservice.ru/en/news..._home_immunomodulators_of_the_last_generation

    I copied the part about Galavit.

     
    Last edited: May 19, 2014
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  19. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    melihtas likes this.
  20. melihtas

    melihtas

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    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472001/

     
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