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New Alzheimer’s treatment fully restores memory function (mice)

Discussion in 'Other Health News and Research' started by anne_likes_red, Mar 18, 2015.

  1. anne_likes_red

    anne_likes_red Senior Member

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    http://www.sciencealert.com/new-alzheimer-s-treatment-fully-restores-memory-function

    Of the mice that received the treatment, 75 percent got their memories back.

    Australian researchers have come up with a non-invasive ultrasound technology that clears the brain of neurotoxic amyloid plaques - structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients.

    There's a link to the abstract of the study in article I liked to.
    (If anyone's interested in a pdf of the full text, PM me.)

    Anne.
     
    Asklipia, Jammy88, Aurator and 14 others like this.
  2. nandixon

    nandixon Senior Member

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    Very interesting. I wonder if this ultrasound technique to "gently open up the blood brain barrier" could be used as a BBB disruption method to achieve better CNS penetration for drugs that otherwise have a difficult time making it through the BBB. Like rituximab.
     
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  3. adreno

    adreno PR activist

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    Huh? The brain already has microglial cells.
     
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  4. alex3619

    alex3619 Senior Member

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    I think the point is the microglia have limitations on their function, and this technique is claimed to increase that function by allowing them more migratory capacity.
     
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  5. adreno

    adreno PR activist

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    So ME/CFS patients could have the opposite problem, i.e., high microglial migration due to a leaky BBB?
     
    Bob likes this.
  6. alex3619

    alex3619 Senior Member

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    Possibly. Hard to say. This might be the case if there is a persistent brain infection, probably non cytopathic.
     
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  7. Aurator

    Aurator Senior Member

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    There's an article here about a new drug called aducanumab, which is claimed to be able to reverse the build-up of amyloid plaques. Having a close relative with fairly advanced Alzheimer's means I generally keep abreast of these sorts of news items.
     
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  8. adreno

    adreno PR activist

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    http://www.ncbi.nlm.nih.gov/pubmed/25563002
     
    Last edited: Mar 22, 2015
    alex3619 likes this.

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