New 23 and me results- help with interpretation

[skwag]

Hi @caledonia ,

But all of that aside, it really doesn't look like MTHFR is at all relevant to causing ME/CFS, since we do have mutations at about the same rate as the general public.

Methylation based disease is a combination of environmental stressors + genetics. If we lived in a perfect non-toxic world, it wouldn't matter how bad your genes were. But we don't.

Is there some logical loophole I'm missing that makes these two statements consistent with one another? I assume by genetics you are referring to defects in MTHFR, MTRR, MTR..... and not some as of yet not considered gene mutations.