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Neurotransmitter report help (nutrahacker)

Discussion in 'Genetic Testing and SNPs' started by jake79, Mar 26, 2016.

  1. jake79

    jake79

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    Could someone more experienced have a quick look at my results and give some feedback if there is something special at my neurotransmitter related genes.

    I've done some supplementation based on these results, but it didn't seem to have any effect.
     
    Last edited: Mar 27, 2016
  2. jake79

    jake79

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    I'll post the results directly here instead of pdf file.


    Neurotransmitter Levels
    rs578776
    CHRNA5
    AG: 1/2
    48.4664%
    Neuronal acetylcholine receptor subunit alpha-5
    Increased nicotine intake


    Neurotransmitter Levels
    rs165722
    COMT
    CC: 2/2
    32.6762%
    Degrades catecholamines, Phase II, inactivates hydroxy-estrogens
    Decreased COMT activity
    Hydroxy B12 (hydroxycobalamin)
    Methyl B12, Methyl donors

    Neurotransmitter Levels
    rs4646312
    COMT
    TT: 2/2
    50.2164%
    Degrades catecholamines, Phase II, inactivates hydroxy-estrogens
    Decreased COMT activity
    Hydroxy B12 (hydroxycobalamin)
    Methyl B12, Methyl donors

    Neurotransmitter Levels
    rs701567
    DAOA
    TT: 2/2
    23.5241%
    D-amino acid oxidase activator, which degrades D-serine, a potent activator of NMDA receptors
    Associated with cognitive manic symptoms
    Idebenone, Piracetam, Magnesium, Taurine, Lithium orotate


    Neurotransmitter Levels
    rs2391191
    DAOA
    AG: 1/2
    49.3000%
    D-amino acid oxidase activator, which degrades D-serine, a potent activator of NMDA receptors
    Associated with cognitive manic symptoms
    Idebenone, Piracetam, Magnesium, Taurine, Lithium orotate


    Neurotransmitter Levels
    rs3749034
    GAD1
    GG: 2/2
    68.6151%
    Catalyzes production of GABA from glutamate
    High glutamate, low GABA
    Taurine, Theanine, NAC,Glycine, Vitamin B3
    MSG

    Neurotransmitter Levels
    rs3828275
    GAD1
    TT: 2/2
    7.46300%
    Catalyzes production of GABA from glutamate
    High glutamate, low GABA
    Taurine, Theanine, NAC,Glycine
    MSG

    Neurotransmitter Levels
    rs3791878
    GAD1
    GT: 1/2
    28.3797%
    Catalyzes production of GABA from glutamate
    High glutamate, low GABA
    Taurine, Theanine, NAC,Glycine
    MSG

    Neurotransmitter Levels
    rs1137070
    MAO-A
    T: 1/1
    N/A
    Oxidizes serotonin, dopamine, epinephrine, norepinephrine
    Increased expression MAO-A
    Curcumin


    Neurotransmitter Levels
    rs2769605
    NTRK2
    TT: 2/2
    10.5874%
    Neurotrophic tyrosine kinase receptor type 2
    Decreased BDNF
    Theanine, Curcumin, Beta-alanine, Lithium orotate, Phosphatidylserine


    Neurotransmitter Levels
    rs2070762
    TH
    A/G
     
  3. Critterina

    Critterina Senior Member

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    Arizona, USA
    Jake,
    What symptoms are you trying to treat? These results would suggest mania, tenancy, depression, bipolar, and others, but unless you have a diagnosis or lab results, it's hard to know what Nutrahacker would suggest might possibly help relieve your symptoms.
    Also, the higher the occurrence, the less likely that the SNP is going to be unique to your situation (outside of being in a gene set, which that program doesn't test for.) For example, we are told that one in five people (20%) experience mental illness sometime in their lives. So if your SNP has an occurrence of 50%, it exists in 50% of the people, way too common to be of use by itself, even in looking for appropriate symptoms.
    Crit
     
    Valentijn likes this.
  4. jake79

    jake79

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    Thanks for replying Critterina.

    Anxiety is my main problem. Perhaps some depression. I think i will do some lab testing and see if could get more information to find the right supplements or medication.
     
  5. Critterina

    Critterina Senior Member

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    Arizona, USA
    Anxiety usually has to do more with the tyrosine/dopamine route than the tryptophan/serotonin route in the BH4 cycle. And of course, methylation is necessary for anything to go forward, and there are a million (more or less) steps after the starting blocks where anything and everything can go wrong. Sorry I can't help you there even by analogy, as I have tryptophan/serotonin issues (more related to depression), not tyrosine/dopamine.

    For me, one of the important tests was the serum amino acids, and I had it done at the same time as the homocysteine, and I and my healthcare practitioner used the Genova Diagnostics key to figure out what was going on. It took a few tries, but I got my numbers in the normal range and feel much better. I hope you can, too.
     

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