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Neurotransmitter in blood, saliva or urine?

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by NotThisGuy, Sep 3, 2017.

  1. NotThisGuy

    NotThisGuy Senior Member

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    Germany
    Hi,
    which test is more accurate for neurotransmitters?
    Blood, saliva or urine?

    @Valentijn or someone, like to hear your opinions.
     
  2. TigerLilea

    TigerLilea Senior Member

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    According to Drs Weil and Perlmutter urine tests are the best for neurotransmitters. Saliva tests aren't accurate. Blood testing is good for checking hormones.
     
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  3. alicec

    alicec Senior Member

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    None of them mean much. Neurotransmitters exist in separate compartments - the blood brain barrier keeps the brain pool quite separate from that of the peripheral nervous system for example. What you see in the blood doesn't reflect the brain while the urine reflects yet another compartment which is influenced by metabolism in the kidneys.

    Here for example is a review which looks at the validity of serotonin and dopamine measurements in urine and concludes they are not valid (apart from well defined conditions like phaeochromocytoma).

    If you search for studies on other neurotransmitters you will find similar problems.
     
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