• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Neuroscience News: What Causes Sleepiness When Sickness Strikes? [in worms..]

Penn roundworm study determines what increases sleepiness during illness.

It’s well known that humans and other animals are fatigued and sleepy when sick, but it’s a microscopic roundworm that’s providing an explanation of how that occurs, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania. A study published this week in eLife reveals the mechanism for this sleepiness.

Working with a worm’s simple nervous system shows how a single nerve cell named ALA coordinates an organism-wide response to sickness. During sickness, cells are under stress, and organisms experience sleepiness to promote sleep and recover from the cellular stress. In the worm, this sleepiness is caused by release from the ALA neuron of FLP-13 and other neuropeptides, a group of chemicals that send signals between brain neurons.
......
These findings reveal that FLP-13 causes sleep by turning down activity in the nervous system cells that help keep an organism awake. Researchers examined genetic mutations to determine which genes cause the worms to fall asleep when FLP-13 is released. This revealed that worms with mutations that cause them to lack a receptor protein called DMSR-1 on cell surfaces do not become sleepy in response to FLP-13. This indicates that DMSR-1 is essential for FLP-13 to trigger sleep.

http://neurosciencenews.com/sickness-sleepiness-5967/

Full paper here https://elifesciences.org/content/6/e19837