I'm wondering if anyone has ever experienced negative effects from P5P? I've taken regular B6 and oral P5P numerous times and felt either nothing or some slight benefit. The P5P brand I was taking previously was the Solgar brand and it seemed fine. I hadn't taken B6 in awhile in either form so I finished off my bottle of Solgar P5P which only had a few pills left. No problems. I then purchased a sublingual P5P and with the first pill I developed severe anxiety and burning/numbness in my hands and feet. The anxiety dissipated within hours but I still have moments of anxiety or depression that pop up the weren't there before. The neuropathy (burning/tingling/numbness) reduced greatly but has never gone away. What is most frustrating is that eating any sort of food or supplement containing even a small amount of B6 will cause an immediate flare of symptoms. I cannot figure this out. It seems to be related to the fact that this P5P was sublingual and went straight into my system perhaps? I've also read that some P5P/B6 is actually contaminated with B6 "mimics" that can block the receptors and cause issues...could this have contaminated what I took? It seems a lot of people who have developed problems taking B6 can never get rid of them and they worsen when any B6 is ingested. Like, I can have very little neuropathy (just a little tingling in my toe) and then I eat a cookie and all of the sudden my arms and feet will burn for hours. Why? Any suggestions? Has this happened to anyone else?