I wasn't scared off by general symtoms, I was scared off by the fact that my daughter became an absolute lunatic after just a tiny dose of methyl B12. She was so out of control and behaving insanely that the school wanted her evaluated immediately at an inpatient facility and while she was autistic at one point, she had never behaved like that. I also didn't mind the diarrhea or rashes I had until it became so painfully awful that I had no choice. While I don't know all the details of each of the COMT defects, I do know that they aren't the whole picture, its the COMT along with the VDR and if you have a full defect in your VDR then you would be able to tolerate methyl B12 without much of a problem. As I understand it, the VDR takes the methyl B12 made at that MTR region and a defect means it isn't taking it so that you can handle having it added into the mix. You could have a partial problem at the COMT +/- with a VDR Taq -/- and not be able to tolerate them very well at all but still be able to have a tiny amount added but if you truly have a VDR Taq -/- along with the COMT +/+ and can tolerate all that methyl B12 than I'd love to see that! Please let me know & if possible, post those tests because I really want to ask my doctor about that next time my daughter has a follow up. To my knowledge, no one has seen that yet and I delved into that a lot back when I was learning it to help Autumn. I have a pretty big biomed group and I didn't come across that there either. But nothing's probably black or white in the end so it would be a good learning point for sure. I agree that detox isn't a reason to avoid any one supplement but I can honestly say that my daughter was frankly psychotic and my metals were pouring out so fast and so heavy I couldn't take the pain anymore. As I explained to Freddd, we didn't have any problems with low potassium at all and had both urine and blood testing so I don't think its as clear cut as it is for some and this is probably due to those pesky genes.