Sharpe is a behaviorist who was involved in CFS for quite a while but who concentrates for on cancer fatigue now. He places CFS in the 'somatoform disorders' category along with FM, IBS, etc. Here they are asking whether there is evidence of neural dysfunction in these disorders and the answer appears to be a qualified yes. As always seems to be the case more and better research needs to be done- but its an intriguing look at the neurological basis of these disorders. Interestingly it focused on the limbic system, which, if memory serves right, Cheney suggested was important early on. What does the Limbic system do? It regulates two systems that are involved in CFS; the endocrine system and the autonomic nervous system. It appears to be tied to flight/fight response This is a large rather, poorly defined system containing these structures Amygdala: Involved in signaling the cortex of motivationally significant stimuli such as those related to reward and fear in addition to social functions such as mating. Hippocampus: Required for the formation of long-term memories and implicated in maintenance of cognitive maps for navigation. Parahippocampal gyrus: Plays a role in the formation of spatial memory Cingulate gyrus: Autonomic functions regulating heart rate, blood pressure and cognitive and attentional processing Fornix: carries signals from the hippocampus to the mammillary bodies and septal nuclei. Hypothalamus: Regulates the autonomic nervous system via hormone production and release. Affects and regulates blood pressure, heart rate, hunger, thirst, sexual arousal, and the sleep/wake cycle Thalamus: The "relay station" to the cerebral cortex.