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Neuroinflammation in the Brain of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

pattismith

Senior Member
Messages
3,930
"In our study using PET scanning, hypoperfusion and low synthesis in the frontal lobe, cingulate gyrus, temporal and occipital cortex, basal ganglia, hippocampus"

Interestingly Cingulate gyrus was also a place with hypometabolism found in 50% of the ME patients in this 2003 study



I also found that Cingulate cortex (Cingulate Gyrus is the main part of the Cingulate Cortex) is affected with hypometabolism in hypothyroidism in this study:

"Thyroid hormone replacement therapy abolished pretreatment group differences in regional activity, robustly increased activity in the ventral ACC (cingulate cortex), and significantly reduced both clinician-rated and self-rated behavioral and psychiatric symptoms.
Increased activity within the ventral ACC was associated with reduced somatic complaints, whereas increased activity within the dorsal ACC was associated with reduced depressive symptoms."