I am doing pretty well in terms of having gotten lithium levels up! and surviving the detox reactions and metal dumping..... Which has been more than unpleasant. I had to back down to a dose of MTHF of around 200mcg every other day and then increase VERY slowly. This has taken about a year. I am still detoxing, and still have daily issues with Potassium low, but it is much more manageable. As well as C677T ++, I have ++ s for some of the genes to do with Folate transport and Folate receptors..... So I am wondering what impact this might have on the dose of 5MTHF that I will eventually need ? My MCV has come down from 108 but has stuck at 101. Anyone had to eventually be on a maintenance dose of, say, 5 mg or so ? I am currently at 1mg twice a day. The half moons on a couple of my fingers have come back..... not seen them for 20+ years !!