I'm struggling with Fred's methylation protocol and so far it's done wonders. I can be up and around and have about 10-12 "active" (in the sense "doing anything at besides resting with my eyes shut") a day instead of just 30 minutes. Lot's of bumps on the road, though. I've discovered that once I don't get enough of something my need for folate skyrockets. It's been too little C, too little Mg, too little Zn. Now I don't know. I need 10 mgs of folate every day to be able to stand up and keep my arms and legs form shaking. I guess that's some kind of paradoxal folate deficiency? I take folic acid since I've noticed no difference between the different kinds of folate before and my MTHFR-test shows I don't have mutations. I've been taking 50-100 mgs of zinc since I notice my need for folate goes down when I take zinc. I'm doing this now: Exclude all folic acid and take metafolin instead. Lower B1 and B2 (I've been taking one B Right/day) Doing tests to see if I lack copper or iron (since Zn might deplete those I'm thinking that might be it. Don't dare to experiment with iron or copper without checking my levels though). Can folic acid cause paradoxal folate deficiency even if you don't have MTHFR-mutations? I guess there might be lots of different problems here? How much folate is normal on Fred's protocol? Before I've only needed 1 mg/day. Any other thoughts on what can cause my high need for folate?