A New Decade of ME Research: The 11th Invest in ME International ME Conference 2016
Mark Berry presents the first in a series of articles on the 11th Invest in ME International ME Conference in London ...
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Need imput from experts

Discussion in 'General ME/CFS Discussion' started by lansbergen, Oct 28, 2016.

  1. lansbergen

    lansbergen Senior Member

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    Do any of you know what symptoms can occur when the body produces large amounts of hydrogen peroxide?
     
  2. trishrhymes

    trishrhymes Senior Member

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    Hi, I don't know anything about this, but it might be worth changing the title to something like 'Need advice on hydrogen peroxide' so anyone who is browsing new threads and can help is more likely to spot it.
     
    Izola and AndyPR like this.
  3. AndyPR

    AndyPR Senior Member

    I'm no expert and neither is Wikipedia but it says
    https://en.wikipedia.org/wiki/Hydrogen_peroxide#Biological_function

    Sorry, none of which is symptoms but perhaps it helps??
     
  4. lansbergen

    lansbergen Senior Member

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    Thanks but I want to know if it can really cause all the symptoms I had and in that severity. I think it can in high enough concentration but I would like conformation.
     
  5. J.G

    J.G

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    You're straying into redox biology territory here. You probably know that hydrogen peroxide (H2O2) is a form of ROS that, since the ETC is not perfect, is produced as a routine by-product of energy metabolism.

    However, we've only recently begun to appreciate H2O2's function as a signalling messenger molecule. It is known to mediate cysteine residues within proteins. H2O2 appears expertly suited for this role since it is able to cross cell membranes. Further, glutathione has little grip on H2O2, for it reacts too slowly with it. H2O2 can perhaps be described as 'benign' form of ROS, since it has preferred biological targets and does not act indiscriminately towards molecules (like HO might, for instance).

    I've found that redox biology is a hard nut to crack. I had a go at the subject when I first began to blog about ME/CFS, and deferred writing about it due to its complexity. If you want to investigate further, these are good articles to get started:

    https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-015-0194-3
    http://www.cell.com/current-biology/abstract/S0960-9822(14)00326-1
    http://www.nature.com/nrm/journal/v8/n10/full/nrm2256.html

    H2O2 pops up in all of them.

    Good luck!
     
    Last edited: Oct 28, 2016
  6. lansbergen

    lansbergen Senior Member

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    Me too.

    Not long ago I found superoxidse is an early immune response.

    Lately I found a path that could fit with how my flares end and why the immune modulator I use helps.

    Superoxide------------->---------------->------------->hydrogen peroxide and then water and oxigen

    I wonder if the intense burning feeling can be caused by high endogenous hydrogen peroxide like the exogenous does.
     

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