The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Need help with putting together methylation mutations../ could someone knowlegdable please help?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Nostos89, Jan 8, 2016.

  1. Nostos89

    Nostos89

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    homozygous:
    MAO-A TT ++
    VDR-Taq AA ++
    MTHFR C677T ++

    heterozygous:
    COMT V158M AG
    COMT H62H CT
    MTRR A66G AG
    MTRR K350A +-
    BHMT-08 CT
    CBS C699T
    CBS A360A

    This is all very mind-boggling for me. It caused my so much stress when I first received the results I had to step away from it for a few months. I have been taking methyl-folate (400 mcg) and methyl B12 since July of last year, though.

    So....

    VDR-Taq++ compined with COMT +- equals moderate need for dopamine/methyl donors, however some of my COMT genes are --, mean HIGH need for dopamine/ methyl donors. I do have symptoms of ADHD, so maybe it could be attributed to this?

    I take 2000 IU of D3. I also take phosphitidyl serine and eat dark chocolate, all of which are methyl donors. I do well with L-theanine and melatonin (methyl donors) Methyl-B12 should be good for me, right? However, the big issue hear is that methyl-folate is supposed to cause issues for the MAO-A ++ gene. But on the other hand, isn't metyl-folate extremely important for me since I'm homozygous MTHFR C677T? Like I said I have been taking methyl-folate in a low dose (400 mcg) for months and do well on it. I also eat a lot of vegetables that contain it. However, I tried increasing to 800 mcg, and felt like I had been hit by a truck and didn't feel right for weeks. I reduced back to 400 mcg. So the question is, should I keep trying to slowly increase my methy-folate because of MTHFR and VDR-taq, or keep it at 400 mcg because of MAO-A?

    Interestingly, I had off-the-charts high levels of B12 and folate before I started either of these supplements so it seems my body is not very good at utilizing them.

    I'm pretty sure I'm OCD, although I don't see a therapist. That seems appropriate for an MAO-A defunct. Prozac and 5-HTP were a nightmare for me, which makes sense if I'm unable to break down serotonin. Can lithium orotate help with the defunct?

    Is a heterozygous CBS mutation a big deal? My homocysteine isn't super-high or low (7). The idea of not being able to eat garlic, onions, or eggs is devastating to me because I love to cook and these foods are the foundation of cooking. I also had an eating disorder and limiting any food causes enormous stress for me which is more unhealthy than anything, I'm sure

    I need help relating how all these malfunctions interact with each other... please help! I guess my biggest question is the methyl-folate needed for MTHFR and VDR-taq but not advised for MAO-A......
     
  2. Nostos89

    Nostos89

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    My lab work is normal except for:

    unexplained elevated bone-specific alkaline phosphatase and intestinal alk phos
    low thyroid
    elevated folate/b12
    low iron
    high cortisol

    symptoms:

    fatigue
    anxiety
    OCD
    depression
    varicose veins

    Please help me if you can!
     
  3. Valentijn

    Valentijn The Diabolic Logic

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    No, those CBS variations have very little or no impact.
     
  4. Nostos89

    Nostos89

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    Thank you for your thoughts! It's a relief to hear that.
     

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