I'm a 30 year old male and recently had my 23andMe tests done. I then ran them through Genetic Genie (since 23andMe isn't really useful for much else at the moment). Here are my results and I'd be very happy to get any input on what I am doing (or not doing) with regards to treatment. BTW, sorry for the length....I like to be thorough. GeneticGenie Methylation SNP profile: COMT V158M +/+ COMT H62H +/+ VDR Bsm +/- VDR Taq +/- MAO-A R297R +/+ MTHFR A1298C +/+ MTRR A66G +/- MTRR H595Y "no call" MTRR K350A +/- MTRR R415T "no call" MTRR A664A +/- BHMT-04 "no call" AHCY-02 "no call" CBS C699T +/- CBS N212N "no call" SHMT1 C1420T "no call" MTHFRSupport Variant Report V1 (methylation profile only): ACE Del16 +/+ ADD1 G460W +/- AGT M235T/C4072T +/- BHMT R239Q +/+ CBS A13637G +/- DAO +/- DHFR +/- FUT2 +/- (rs492602, rs601338, rs602662) GAD1 +/- (rs3749034, rs2241165, rs12185692, rs10432420) GAD1 +/+ (rs2058725, rs3791850) MTHFS +/+ MTHFD1 C105T +/+ MTHFD1L +/- MTHFR +/+ (rs1476413, rs3737964, rs4846048, rs4846049, rs6495446) MTRR-11 A664A +/- MTRR +/- (rs1532268, rs9332) NOS2 +/- (rs2297518) NOS3 +/- (rs1800783, rs1800779, rs3918188) PEMT +/+ (rs4646406) SHMT2 +/- TCN2 C766G +/- GeneticGenie Detox SNP profile: CYP1B1 L432V +/- CYP1B1 N453S +/- CYP1B1 R48G +/- CYP2C9*2 C430T +/- CYP2D6 S486T +/- CYP2D6 2850C>T +/- GSTP1 I105V +/- NAT2 R197Q +/+ GSTT1 "Present" For most of my life I have had bad ADHD, anxiety, IBS, low blood pressure issues, mood swings, short term memory issues, chronic fungal and bacterial infections, dysrhythmic gait and speech, migraines, chronic brain fog and chronic fatigue. I also recently experienced peripheral neuropathy (PN) due to the buildup of ammonia in my body damaging nerves. Luckily I figured out the cause soon enough to reverse most of the PN damage. The other symptoms have been ameliorated, but I'm not at 100% yet. Switching to a fairly strict slow carb slightly ketogenic primal/paleo based diet has helped immensely. I'm a celiac so I avoid gluten like the plague. Most of my IBS symptoms and fatigue cleared up when I got off gluten and started eating unpasteurised probiotic rich foods. My diet is pretty much steady, consisting of the following ingredients ingested almost every day in some form or fashion: Spinach (1 cup) Cauliflower (1/2 cup) Broccoli (1 cup) Onions (1/4 cup) Sprouted lentils (1 cup) Avocado (1 large) Baby portabella mushrooms (1/2 cup) Kale (1/2 cup) Tomatoes (1 small) Asparagus (1/2 cup) Chia seeds (4 tbsp) Dark cherries (1/4 cup) Blackberries (1/4 cup) Almonds (2 tbsp) Brazil nuts (just 1) Hazelnuts (2 tbsp) Cashews (1 tbsp) Sesame seeds (1 tbsp) Eggs (4) Chicken breast (1-2 large) Ground turkey/beef (1/2 cup) Coconut oil (1-2 tbsp) Black walnut oil (1 tbsp) Coffee (1-2 cups half-calf) Green/White tea (2-3 cups) Iodized salt (1 tsp) 85% dark chocolate (10-20 g) Almond Breeze Unsweetened Vanilla (1 cup) 1 scoop Optimum Nutrition Chocolate Natural Whey Protein (sweetened with stevia) 10-20 g L-Glutamine powder (for leaky gut repair and after workout glycogen recovery) All ingredients are cooked below 225 degrees. I have 1-2 glasses of wine or a gluten free beer once per month (sometimes twice). I am currently taking the following supplements daily to correct for these genetic conditions: 1 cap Vitacost Synergy Optimized B-100 Complex (importantly contains 100 mcg methylcobalimin and 800 mcg (6s)-5-methyltetrafolic acid) 350 mg Jarrow Formulas N-Acetyl Tyrosine (CBS and NAT2 have me questioning this) 150 mcg Country Life Chelated Molybdenum 4,000 IU Vitamin D3 (questionable whether it helps VDR) 10 mg Albion Manganese Glycinate Chelate 400 mg Swanson Triple Magnesium Complex (350 mg magnesium oxide, 40 mg magnesium citrate, 10 mg magnesium aspartate) 15 mg Zinc + 1 mg Copper complex Some other supplements I take that may or may not have an impact on the activity on these SNPs but help with other issues: Vitacost KriaXanthin (2,000 mg Antarctic krill oil, 3 mg astaxanthin) Vitacost Mega EFA (2,126 mg fish oil, 800 mg EPA, 400 mg DHA) 2200 mcg LifeExtension Super K with Advanced K2 Complex (1000 mcg K1, 1000 mcg K2 MK-4, 200 mcg K2 MK-7) 1000 mg SerinAid (200 mg phosphatidylserine, 90 mg phosphatidylcholine, 20 mg phosphatidylethanolamine) (questionable if it helps boost serine levels, which SpectraCell shows I am low on) 300 mg LifeExtension Super R-Lipoic Acid (Na-RALA; supports glutathione production) 350 mg Rhodiola Rosea Extract (250 mg rhodiola rosea root extract, 100 mg rhodiola rosea root) 600 mg Kyolic Aged Garlic Extract (For my ApoE cholesterol levels. Debatable if it really helps.) While the above have helped, they aren't working as well as I would like so I believe further tweaking (or a complete revision) is necessary. I keep reading that taking hydroxycobalamin is important with COMT++, but that has been almost impossible to find. I keep finding hydroxocobalamin instead. Are they the same thing? Does this form of B12 have to be taken sublingually for proper absorption? I also take the following for my back pain caused by disc degeneration (works great) but I am concerned about the sulphur content affecting me unfavorably due to these genes (should I be?): 1,500 mg Glucosamine Sulfate 1,200 mg Chondroitin Sulfate 1,000 mg MSM Tests have shown I have slightly elevated ALT (43 IU/L) and below normal ALP (39 IU/L), both of which suggest my liver is stressed by the extra work it is doing thanks to these genes. What's worse, I have the ApoE variant meaning my liver has a hard time clearing cholesterol from my blood. I was taking 150 mg of Milk Thistle daily to help with this, but I found out it could potentially cause an increase in estrogen so now I'm not so sure about it. I was also taking 600 mg NAC for my liver but realizing I am CBS C699T+- and NAT2 R197Q++ has made me rethink that due to the sulphur and acetylation pathways this can interact with. The biggest problem I am facing is how to reconcile the interplay of these genes because some seem "opposed" (for lack of a better term) to each other in some respects, especially when it comes to their effects on methylation. I really need to find an optimal balanced solution for all my genes involved, so any input on my supplement regimen and diet as it relates to my genetics would be very much appreciated!