I have converted my 23andMe results to Yasko's format (using the spreadsheet), and this is what I got: CBS A360A +/- CBS C699T +/- COMT H62H +/- COMT V158M +/- COMT-61 P199P -/- MAO A R297R + MTHFR C677T +/- MTHFR A1298C -/- MTHFR03 P39P -/- MTR A2756G +/- MTRR H595Y -/- MTRR K350A -/- MTRR R415T -/- MTRR A66G +/+ MTRR-11 A664A -/- VDR Bsm/Taq +/+ ACAT1-02 +/- AHCY-01 -/- AHCY-02 -/- AHCY-19 -/- BHMT-02 +/- BHMT-04 +/- BHMT-08 +/- SHMT -/- Right off the bat I can see that I am heterozygous for 2 CBS, and 3 BHMT SNPs. As I understand it, those give me a higher need for methyldonors, and also a propensity to accumulate ammonia and sulfite/sulfate. I am heterozygyous for 1 MTHFR (C677T) and MTR. MTRR are normal, except I'm homozygous for A66G. Again, all this would indicate that I need more methylfolate, more methylcobalamin, and methyl donors. Then comes the confusing part. I am heterozygous for 2 COMT, but VDR (bsm/taq) is +/+. As I understand it, COMT +/- combined with VDR +/+ behaves like COMT -/-. So what does this mean for my methyl donor tolerance? My personal experience is that I am sensitive to both dopamine, and methyl donors. But at the same time I have attention issues, and seems to need dopamine to wake up my brain, even though it gives me anxiety, mood swings and irritability. I have tried 2-5mg of each methylfolate/methylcobalamin for the past three months, but didn't do well on them. Brain fog was severe, and I felt very unstable in a biochemical sort of way. Electrolytes were way off. Can anyone make suggestions to what supplements I should take? Would hydroxycobalamin be effective in this scenario? How much methylfolate I am likely to need? Should I take TMG? I have been taking both P5P and ALA in the past, but if Yasko is correct about CBS upregulation, I should probably drop them. Instead I am thinking of adding 150mcg molydenum, and some phosphatidylcholine. I am unsure about the TMG. Thank you for any help and comments. This is confusing stuff.