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Need help interpreting 23andMe results.

Discussion in 'Genetic Testing and SNPs' started by Mercy, Jul 3, 2013.

  1. Mercy

    Mercy

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    Help! Because of severe neck pain, my time on a computer is limited to a few minutes a day. As I am sure you can imagine, this makes performing any research terribly challenging. I would be extremely grateful for any assistance analyzing my data.

    METHYLATION

    homozygous:
    BHMT-02 rs567754 TT
    BHMT-04 rs617219 CC
    BHMT-08 rs651852 TT

    heterozygous:
    VDR Bsm rs1544410 CT
    VDR Taq rs731236 AG
    MAO-A R297R rs6323 GT
    MTRR A66G rs1801394 AG
    MTHFR C677T rs1801133 AG
    AHCY-01 rs819147 CT
    AHCY-02 rs819134 AG
    AHCY-19 rs819171 CT
    CBS A360A rs234706 AG


    DETOX

    homozygous:
    CYP1B1 L432V rs1056836 GG
    NAT2 I114T rs1801280 CC
    NAT2 K268R rs1208 GG

    heterozygous:
    CYP1B1 R48G rs10012 CG
    CYP2C19*17 rs12248560 CT
    CYP2D6 S486T rs1135840 CG
    CYP2D6 100C>T rs1065852 AG
    CYP2E1*1B 9896C>G. Rs2070676 CG
    GSTP1 I105V rs1695 AG

    Thank you!
     
  2. Misfit Toy

    Misfit Toy Senior Member

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    Mercy, "Living Wellness" on Facebook...the guy's name is Thane. He studied Yasko's work and Rich V's. He can help you with this. It's not expensive. He has put me on a simple protocol to start. Just a thought. Best of luck!
     
  3. Mercy

    Mercy

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    22
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    Thanks for the info, Misfit Toy. I will check him out.
     
  4. caledonia

    caledonia

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    1,558
    Cincinnati, OH, USA
    You have one First Priority mutation which is the CBS A360A. That's the minor one and you're only hetero for that, so it may or may not be an issue by itself. However, the BHMT 2 and 4 can add to CBS and even cause CBS type problems even if you don't have the SNP.

    You can check your sulfate levels with CTL scientific sulfate strips. Signs and symptoms of problem would be problems with sulfur containing foods/meds/supps and/or a stress/anxiety reaction when starting methyl containing supps (B12, folate, TMG).

    Address CBS before starting on the rest of the SNPs. The Heartfixer page has a good CBS protocol. I did that protocol and was successful with it. The only change I made was to use the Free Thiol diet instead of a low sulfur diet.

    Once you have that taken care of, everything else should be pretty straight forward. So some methylfolate, some B12, TMG, etc. and the various co-factors. You may be able to simply do Rich's simplified protocol with some tweaks on the kind of B12*.

    The AHCYs are supposed to take care of themselves if you address the rest of the methylation cycle.

    With VDR bsm you should get your vitamin D levels checked.

    *The VDR taq will work with COMT to suggest what kind of B12 to take. Yasko has a nice chart on her Simplified Roadmap. So that would be all three kinds of B12 (hydroxy, adenosyl, and methyl) with less methyl.

    I have links to all the things mentioned in my signature.
     
  5. Mercy

    Mercy

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    Thank you, Caledonia! I really appreciate that you took the time to look over my results. It sounds pretty straightforward the way you described it.
     

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