I need help with my 11 year old. He has been diagnosed with Lyme, anxiety, aspergers and PANDAS. We recently received his 23andme results and he has the following SNPs: Homo: COMT V158M, COMT H62H, MAO-A Rs97R, MTRR-11 A664A, ACE Del16 Hetero: VDR Bsm, VDR Taq, MTHFR C677T, MTHFR A1298C, AHCY-01, AHCY-19, CBS C699T, CBS A360A We treated the Lyme for 3 month with abx but stopped 3 weeks ago because he was having such a hard time. Our plan is to start Samento/Banderol soon. He is extremely depressed, irritable, high anxiety over the littlest problems, very difficult to get him to school. We are working with a biomed dr, chiro and lyme naturopath but he's just gotten worse over the past few months. Now that we have the 23andme results I feel like there is a whole new host of problems that we need to address. I've downloaded Amy Yasko's recommendations and now need to discuss them with his biomed dr but it looks as though we first need lay the groundwork by adding in the all-in-one general vitamin and get his glutamate/gaba levels in balance with the Be Calm Spray. I'm just overwhelmed. Does anyone have any other suggestions based on the SNPs noted above? What about SSRI's? I have tried to avoid them but he is seriously depressed. I give him Xanax when he is particularly anxious or having a panic attack but I feel like he needs something more. I thought I read somewhere that SSRI's aren't recommended if you have these SNPs. Any thoughts or recommendations would be greatly appreciated. We are really struggling.