My recent downfall after stopping SMP supps from what I can tell has been remedied by taking Cobalamin. I had an initial great reaction to a small amount (100-200 mcg) of Hcbl but there are some side effects I'm having with. I switched to MCbl and feeling more like a normal person again. Mentally better (depression gone), gut is much much better. This leaves me with a couple of questions. 1. What is it about the HCbl that doesn't seem to be as effective (making me feel as good) as MCbl? I'm tempted to think it might be doing something good (generating ACbl?) that I need and I should "tough out" trying it. 2. I am MTR+/- and 2 MTRR++ (corrected), while only MTHFR +/- (see tag line for specifics). So from my genetics is it possible I only need to supplement with MCbl and NOT folates? If folates are eating up MCbl then if I already have enough in my system and my MTHFR mutations aren't blocking them then if I supplement folates can that deplete my MCbl and end up where I have been the last 6 weeks (feeling awful) MethylTrapped with a MCbl deficiency? I know I have seen suggestions to start SMP with just MCbl (or HCbl). Maybe that is prudent especially for those with my genetics?