My rheumatologist wanted me to start on LDN. I have been on the fence because I took it years ago and didn't sleep. Since I am not regulated on my thyroid meds, I was unsure but my GP said..."go for it." Well, I took .5 yesterday at lunch and was up most of the night. I am not even sure I slept. Does anyone take a smaller dose and should I even be doing this now considering that I am already so ill from the thyroid being out and not being optimal on my meds? I am not sure. The last thing I need is to not sleep. That is not even an option.