So, I have been using methylation supps for a few years now, with good result. I am looking at trying to add on to what I already take, to see if I can bring it to the next level, and help address some migraine like symptoms I have been dealing with lately. Here is what I take: Methylcobalamin Dibencozide Potassium Methylfolate Choline B-Multi (no b-12) ....and that's it, really. I have other supplements as well, but those are only taken on an as needed basis. I am looking at adding either: Sam-e or acetyl l carnitine. I tried the carnitine a few years back, but don't remember much about it. The Sam-e I have never used. If I only could pick one, what would make better sense from your experience?