This is my first post, please go easy on me. I am 30 years old and have MTHFR double hetero. Since about November I have felt spacy, it became permanent about February and seems to be progressing. I have been trying my best to take Mb12 and Methylfolate, but they make me crazy like nothing I have ever felt before. But it did improve my neuropathies, feet and hands don't tingle as much and tremors have subsided some, I can sleep now. I was taking Hydroxy B12 and a B-complex to stabilize but over time I developed worse food sensitivities. When I started the Mb12 I was taking Penicillin and stopped both at the same time, ended up in the ER drinking coconut water to calm low potassium symptoms drank two in an hour or so,my stomach has been funny ever since. I have severe exercise intolerance that progresses every day, last thursday I was walking stairs at work and I turned cold, purple and lightheaded I sat down, told someone this week I have been having blood sugar issues (just popped up, possibly yeast, or green diet, blood sugar has always been high/normal 80-130). Anyway they called an ambulance and I was told to take time off of work. I have spent over 10K on doctors and lab tests and am almost tapped out. Living with my fiancee's grandparents who are extremely irritated with me, getting married in a month. Yesterday I ate very little took some B6 and Mag/Zn to calm the histamine responses it made my skin burn, when I took Mag/Zn it would stop, best sleep in 6 months. But still extremely sensitive to starches, ate some rice made me lightheaded and blood would be thin when I checked it for blood sugar. When I eat I get very lightheaded/spacy, lately Blood sugar is 70-100 and BP usually 125/85. Got heavy metal hair test 5 times upper range on Manganese, manganism? 2 times upper limit on Barium. Have worked in fab shops most of my life. Lower end of range Cobalt, B12 deficient? And low Iron (used to eat lots of red meat), caused by high Manganese? My main question is why am I overly sensitive methylfolate deficient? Yeast? MCAD? All of the above? I can remember when this started I was sensitive to wine/beer, slow cooked meats, fish all high histamine foods, now a histamine liberating food messes with me too. Also, when I tried methylfolate I licked the 400mcg solgar metafolin within 30 minutes my heart was at 120bpm and stayed that way for three days had to take klonipen to sleep, I became super sensitive to B12 again. I had my DHEA-S and testosterone tested they indicate I am in the middle stages of adrenal fatigue, DHEA-S 350 (highish, body fighting) testosterone 190 (low body under stress). My calcium has been in the highish ranges at times 10.9 once, check PTH twice was good, lately not eating much lost 50 pounds and calcium is around 9.8. I have seen numerous doctors, two naturopathic MDs one strongly believes my problems are mold exposure lived in moldy home for 1.5 years wants a C4a, lipids, pregnenolone, Lyme Western Blot (I am almost out of money don't know if I should). The other is waiting on porphrins, stool CP, glutathione, oats, edta challenge, neurotransmitters. I felt better when I took xanax and klonipen a few months ago but stopped, I read they are powerful antihistamines as most anti-anxietys are. I am thinking my methylation is screwed up, causing histamine issues, with some form of toxicity (mold, metals), compounded by MTHFR, a family history of food reactions (lightheaded), great grandmother died only eating lettuce, cousins keep food diaries food makes us loopy. I have also had some kidney irregularities, when I was working out November I weighed about 210, and they found proteinuria, hematuria and low creatinine excretion, I have horizontal ridges in my fingernails from about that time. I am now about 160 and can just walk, feeling like I am always drunk. I went to LSU graduated in biology top of my class 3.8 science / math 4.0 chemistry minor. If/when I get better I want to go into research to solve these problems. Please give whatever advice you can.