Hello, I've had two Methylation Pathway Panels, 4 months apart. The second one showed good improvement just from the classic Simplified Protocol, but there is still clear methylation cycle dysfunction per Dr. Van Konynenburg's typical characterization of a Methylation block (depleted GSH, depleted SAMe, etc). The protocol has been great, but I have noticed when I'm making my best gains I've noticed intense neck and back muscle tightness and pain. Its like some critical nutrient is being sucked up and my neck muscles are constricting. I get plenty of potassium from coconut water, bananas and tablets. This effect is not proportional to potassium. I figured there was some amino acid I was using up, so I've supplemented glycine and NAC, but that doesn't resolve the issue either. Any advice would be greatly appreciated.