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Naviaux et. al.: Metabolic features of chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by A.B., Aug 29, 2016.

  1. A.B.

    A.B. Senior Member

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    The Naviaux study we have been waiting for

    Metabolic features of chronic fatigue syndrome


    http://www.pnas.org/content/early/2016/08/24/1607571113.long
     
    pattismith, Joh, Stretched and 70 others like this.
  2. Ben Howell

    Ben Howell OMF Correspondent

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    Hot off the press! Nice one!

    Unbelievably significant.

    It's gonna go off!


    B
     
    Last edited: Aug 29, 2016
    Jennifer J, Advocate, moosie and 11 others like this.
  3. gregh286

    gregh286 Senior Member

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    Stress induced metabolic pathway alterations. Wow
     
  4. A.B.

    A.B. Senior Member

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    This is half the answer. The other half is figuring out why this state persists for so long.

    It feels like we're really close to understanding this disease. And once you understand the problem, coming up with a treatment could be quite simple.
     
    pattismith, Joh, LSLJ and 34 others like this.
  5. charles shepherd

    charles shepherd Senior Member

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  6. snowathlete

    snowathlete Not an ol' sleazebag

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    Joh, L'engle, Wolfiness and 16 others like this.
  7. Ben Howell

    Ben Howell OMF Correspondent

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    "Area under the receiver operator characteristic curve analysis showed diagnostic accuracies of 94% [95% confidence interval (CI), 84–100%] in males using eight metabolites and 96% (95% CI, 86–100%) in females using 13 metabolites."
     
    Barry53, L'engle, PennyIA and 10 others like this.
  8. snowathlete

    snowathlete Not an ol' sleazebag

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    UK psychiatrist (who is commenting on CFS story, why?) says a lot more work to be done yet, well there was my second shock.
     
    Joh, L'engle, Advocate and 8 others like this.
  9. dancer

    dancer Senior Member

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    Why on earth did the daily mail interview a psychiatrist for comment? And when will we stop being besieged by the "this might show it's not all in the mind" narratives? How many times must that be shown before that stops being the go-to focus? Sigh.

    But the study does sound intriguing. My brain can't quite follow it all...so I'm hoping for analysis from all the great science minds on this forum.
     
    Helen, Joh, Keela Too and 23 others like this.
  10. Sidereal

    Sidereal Senior Member

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    Who is this randomer from Edinburgh and why is he of all the people in the world being asked to opine on a metabolomics study?
     
    Joh, J.G, picante and 16 others like this.
  11. Sidereal

    Sidereal Senior Member

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    Might be worth adding Naviaux to the thread title, lots of people have been anticipating the publication of his study and the title of the paper is a little vague.
     
    L'engle, Advocate, Solstice and 6 others like this.
  12. Cheshire

    Cheshire Senior Member

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    gretac, Harown, L'engle and 18 others like this.
  13. Groggy Doggy

    Groggy Doggy Mermaid.....lost on land

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    PDF version
     

    Attached Files:

    L'engle, Advocate, Solstice and 10 others like this.
  14. deleder2k

    deleder2k Senior Member

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    What will the psychobabblers say about this study? That the proposed test isn't worth anything because we don't know if people that are depressed or that have other diseases carry the same abnormalities..?
     
    L'engle, Advocate and Hutan like this.
  15. alex3619

    alex3619 Senior Member

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    Not like a rocket, more like a TARDIS!!!
     
    gretac, George, temple88 and 16 others like this.
  16. Ben Howell

    Ben Howell OMF Correspondent

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    This is being addressed as part of OMF's future study i.e checking the biochemical 'signature' against other illnesses.


    B
     
    L'engle, Advocate, caledonia and 15 others like this.
  17. deleder2k

    deleder2k Senior Member

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    Like this?? [​IMG]
     
    gretac, temple88, L'engle and 11 others like this.
  18. Ben Howell

    Ben Howell OMF Correspondent

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    Would like to hear your thoughts on it @alex3619.


    B
     
    Advocate, TiredSam and deleder2k like this.
  19. Bob

    Bob

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    Weblink to download the PDF (early version) from the website:
    http://www.pnas.org/content/early/2016/08/24/1607571113.full.pdf

    It's best to download the PDF from the website, for two reasons:
    1. To get the latest version. (With edits and corrections etc.)
    2. So that the journal gets to count the download hits.
     
  20. gregh286

    gregh286 Senior Member

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    Londonderry, Northern Ireland.
    lipid groups with over 80% metabolic impact in the study.
     
    Gondwanaland and Advocate like this.

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