The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Nature Review: Gut Microbiota

Discussion in 'Other Health News and Research' started by Waverunner, Oct 5, 2012.

  1. Waverunner

    Waverunner Senior Member

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    Hi all,

    Nature just released a Nature Reviews Gastroenterology & Hepatology, that focuses on gut microbiota and future developments. There are quite a few articles, which can be viewed for free. You can find it here:

    http://www.nature.com/nrgastro/focus/gutmicrobiota/index.html?WT.mc_id=FBK_NPG

    I wanna pinpoint to the most interesting parts:

    http://www.nature.com/nrgastro/journal/v9/n10/pdf/nrgastro.2012.172.pdf

    ...First, they found that mice with colitis
    had lower diversity in their gut microbiota
    than wild-type mice, with a shift in
    microbial composition towards increased
    numbers of commensal Escherichia coli
    (a 100-fold increase when intestinal
    inflammation was present).
    Crucially, the authors next confirmed
    that E. coli specifically had a role in CRC development..

    http://www.nature.com/nrgastro/journal/v9/n10/pdf/nrgastro.2012.157.pdf

    "New findings demonstrate novel interactions between diet, bacteria, genetic susceptibility and immune
    responses in IBD. Milk fat increases production of taurocholine-conjugated bile acids, which promotes growth of sulphate-reducing bacteria that cause immune-mediated colitis in susceptible mice. These observations will guide human studies that might improve dietary advice for patients with IBD"

    http://www.nature.com/nrgastro/journal/v9/n10/pdf/nrgastro.2012.156.pdf

    The microbial communities that colonize different regions of the human gut influence many
    aspects of health. In the healthy state, they contribute nutrients and energy to the host via the fermentation of nondigestible dietary components in the large intestine, and a balance is maintained with the host’s metabolism and immune system. Negative consequences, however, can include acting as sources of inflammation and infection, involvement in gastrointestinal diseases, and possible contributions to diabetes mellitus and obesity.

    http://www.nature.com/nrgastro/journal/v9/n10/pdf/nrgastro.2012.152.pdf

    Studies that used these technologies indicate that dysbiosis (that is, abnormal microbiota
    composition) and decreased complexity of the gut microbial ecosystem are common features in patients with Crohn’s disease or ulcerative colitis. Whether such changes are a cause or a consequence of the disease remains to be elucidated.
     
    Adster, Sherlock and merylg like this.
  2. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

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    Czechosherlockia, USA
    Thanks for the pinpointing, it saves us time.
     
    Little Bluestem likes this.

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