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9th Invest in ME International ME Conference, 2014 - Part 1: Autoimmunity and ME
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Naturally occurring polymorphisms of the mouse gammaretrovirus receptors

Discussion in 'XMRV Research and Replication Studies' started by Jemal, Jul 12, 2011.

  1. Jemal

    Jemal Senior Member

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    This is from the lady that researches GaLV, XMRV and gibbons and got large funds from the NIH. Might be an interesting read. There's a section about XMRV on page 20, 21 and 22.

    http://www.hindawi.com/journals/av/aip/975801/
  2. Jemal

    Jemal Senior Member

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    This paper is mostly beyond my ability to understand. I found this to be a weird quote:

    Are they saying XMRV could only infect two species of hamsters and one species of gerbil?
  3. OverTheHills

    OverTheHills

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    Hi Jemal,
    No, I don't think they're saying XMRV can only infect some hamsters and gerbils.
    The highlighted sentence says 'Restricted by' not 'restricted to' , I'm assuming they are talking about things like APOBEC3? aren't they known as restriction factors?

    Hope that helps, I don't understand this level of science AT ALL.
    OTH
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Hi, restriction factors restrict the virus in its capacity in some way: sometimes they destroy the virus, sometimes they just alter it a little. Bye, Alex
  5. RedRuth

    RedRuth Senior Member

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    This is really interesting and much more up my street, research wise. I suppose it's basically about the on going arms race between virus and host. WRT XMRV she says These results suggest that XMRV differs from other X-MLVs in its
    interaction with XPR1 receptor determinants, and also suggest that XMRV may be uniquely dependent on an as yet unidentified receptor cofactor
    which means it may interact with a different part of the XPR1 protein and that there may be a secondary co factor that that isn't needed by other MLVs. she doesn't say anything about host restriction factors like APOBEC or tetherin/CD317.
  6. Mark

    Mark Acting CEO

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    If this has grabbed your interest, RedRuth, then Kozac's earlier papers on XMRV should be of great interest too, as well as the response of some of the scientists here to them.

    This one from Dec 2010 was much discussed here: the most extraordinary factor, as I recall, was that (I think) this was the study that estimated the emergence of XMRV to roughly a 30-year window, in a specific species of mouse which lives only in the area where what may have been the first ever outbreak of ME occurred - Los Angeles 1934: the time-frame and location are just right for the origin of XMRV and ME to coincide! I mention that because that connection is a good example of the sort of information that knowledgeable people within the ME/CFS community have at their fingertips, and which researchers focused on a specific discipline may lack...anyway, this research should be very interesting to you I suspect, if you haven't seen it already...

    http://forums.phoenixrising.me/showthread.php?8879
    http://phoenixrising.me/forums/entry.php?685-Contamination-is-DOA&bt=3652

    And here's the rest of Kozac's XMRV research in PubMed:
    http://www.ncbi.nlm.nih.gov/pubmed?term=kozac%20xmrv
  7. Jemal

    Jemal Senior Member

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    Thanks for your reply OTH!
    It does seem I interpreted the sentence wrong. It's the other way around: there's a few species of hamsters and gerbils that can restrict XMRV.
  8. RedRuth

    RedRuth Senior Member

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    Interesting stuff. I have now found some information on host restriction factors and XMRV. Apparently both Human and Mouse tetherin/CD317 and APOBEC restrict XMRV efficiently and there doesn't seem to be any viral accessory proteins that counteract these factors (like Vpu - an HIV-1 accessory protein). This has important implications as PBMCs and all hematopoietic cells express tetherin/CD317. If XMRV is an infective Human virus it's not likely to replicate in these cells. http://www.pnas.org/content/107/11/5166.full

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