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Natural Ways to Lower Plasma Norepinephrine?

Discussion in 'General Treatment' started by Emootje, Aug 9, 2011.

  1. Emootje

    Emootje Senior Member

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    My high norepinephrine level is responsible for many of my symptoms (nausea, burning skin, agitatie, immunesuppression and anxiety). Deep breathing (lowers norepinephrine) is working very well for me. I was wondering if I could extend this benefit by reducing norepinephrine even further with supplements.

    These are my ideas so far:
    *Increase degradation: MAO? (cofactors: copper, iron, riboflavin, vitamin C), COMT?
    *GABA? (theanine, kava, skullcap, valerian, GABA)
    *Lithium orotate
    *Increase serotonin? (5-HTP)

    Anyone experience with norepinephrine lowering supplements?
    I need some advice...
     
  2. Emootje

    Emootje Senior Member

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    Anyone experience with Reserpine? (Respen-A, Serpina)
    Reserpine is able to deplete catecholamines by blocking VMAT and MAO-A which result in a decrease in norepinephrine, histamine and serotonin.
    Dr. Woeller uses Respen-A in autistic children with good results. http://www.autismrecoverytreatment.com/
    For more information on MAO-A deficiency: http://vimeo.com/25541653

    Summary:
    MAO-A deficiency is caused by:
    * low MAO-A active allele
    * mercury
    * aluminium
    * cadmium
    * copper toxicity
    * estrogen
    * stress
    * lipid peroxidation

    MAO-A deficiency causes:
    * impaired ATP production > increased lactic acid (low MAO-A inhibits KGDH and NADH dehydrogenase)
    * increased norepinephrine.
    * increased histamine
    * increased serotonin
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    phosphatidyl serine can help lower cortisol levels, cortisol is basically a long acting adrenaline so controlling it would help. I have had some success with this at night with tryptophan for sleep, in saying this im not the best sleeper in the world by a long shot, but this has helped.

    cheers!!!
     
  4. Emootje

    Emootje Senior Member

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    In the previously mentioned video, Elaine Delack stated that cortisol promotes copper accumulation. Copper decreases norepinephrine degradation by lowering MAO-A activity.
    I guess phosphatidyl serine could work by lowering cortisol induced copper accumulation which promotes norepinephrine degradation by increasing MAO-A activity.
    Thanks Heapsreal!

    mao-a.JPG
     
  5. richvank

    richvank Senior Member

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    Hi, Emmotje.

    Lifting a partial block in the methylation cycle will help to lower norepinephrine in two ways. One is that it raises SAMe, which is used by COMT to break down norep as you mentioned. The other is that SAMe is needed to convert norep to epinephrine.

    Best regards,

    Rich
     
  6. Emootje

    Emootje Senior Member

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    This makes a lot of sense.
    Thanks Rich.
     

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