Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Natural killer cells in human autoimmune diseases

Discussion in 'Other Health News and Research' started by heapsreal, Oct 26, 2015.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999796/

    Natural killer (NK) cells have been implicated in tumour surveillance and in the early control of several microbial infections. In autoimmune disease their involvement in these processes has been evaluated in animal models, with conflicting results. Both a disease-controlling and a disease-promoting role have been suggested. In human autoimmune disease only a few studies, mainly descriptive, have demonstrated qualitative and quantitative modification of NK cells. These changes were observed on blood- or tissue-infiltrating NK cells. Taken together with our expanding knowledge of the genetical variability of NK cell receptors and NK cell physiology, these findings pave the way for the dissection of the role of NK cells in human autoimmune diseases. NK cells may be directly involved in these diseases through their potential autoreactivity or through their interaction with dendritic cells, macrophages or T lymphocytes, thereby inducing excessive inflammation or favouring the adaptive autoimmune response. Thus, Natural killer (NK) cells have been implicated in tumour surveillance and in the early control of several microbial infections. In autoimmune disease their involvement in these processes has been evaluated in animal models, with conflicting results. Both a disease-controlling and a disease-promoting role have been suggested. In human autoimmune disease only a few studies, mainly descriptive, have demonstrated qualitative and quantitative modification of NK cells. These changes were observed on blood- or tissue-infiltrating NK cells. Taken together with our expanding knowledge of the genetical variability of NK cell receptors and NK cell physiology, these findings pave the way for the dissection of the role of NK cells in human autoimmune diseases. NK cells may be directly involved in these diseases through their potential autoreactivity or through their interaction with dendritic cells, macrophages or T lymphocytes, thereby inducing excessive inflammation or favouring the adaptive autoimmune response. Thus, NK cells may be implicated in the onset, the maintenance or the progression of autoimmune diseases. Some reports also suggest the involvement of NK cells in the treatment of human autoimmune disease by biotherapies. All these observations suggest that NK cells are involved in the complex processes of autoimmune diseases. Nevertheless, further careful analysis of NK cells at different steps of these diseases, in different tissues and through combined genetical and functional studies will contribute to a better understanding of their role in autoimmune diseases. This knowledge might allow the development of new therapeutic strategies based on NK cells for the treatment of some autoimmune diseases.

    NK cells have been first described by their ability to kill leukaemic cells without prior sensitization. They represent a small proportion of blood lymphocytes and do not express a specific receptor for antigens, as do T and B cells. NK cells have been implicated in tumour surveillance and in the early control of microbial infections, including infections with viruses (such as herpesvirus) and intracellular parasites.
     
  2. Ecoclimber

    Ecoclimber Senior Member

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    @heapsreal Heaps, you already post a thread on this awhile back.
     
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Did i ? Haha
    I guess that ticks the box for cognitive issue with low nk function.
    A review is always good.
     
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  4. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I haven't had a computer for a while now, just my phone. So normally have studies i posted saved, but not on my phone.

    There are several things i have posted online in the past and later done a google search and find someone commenting on something cfs related. I usually start reading it go wow ok i agree with this dude but as i read on i realize its something I have posted. Lol
     
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  5. lnester7

    lnester7 Seven

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    @heapsreal Welcome Back!!!! I struggle w low Nk (COUNT vs Activity) but LDN raised it better than the immunovir. Dr K told me that even though 4.5mg is a target does not mean you cannot increase and see if that helps. I am on 9mg now and I can see NK raising. Will get tested and again and will keep you posted.
     
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  6. leokitten

    leokitten Senior Member

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    @heapsreal and others I would say that one of the most important findings mentioned in this review as it relates to ME, and this is something that his been known in autoimmune diseases for quite a long time, is this:
    Reduced NK cell numbers and function are found in a number of autoimmune diseases. While it's true that reduced NK cell numbers and/or function are not specific to autoimmune diseases and can also happen due to severe or chronic infection, its still another piece of evidence that ME could be an autoimmune disease.

    Also if anyone does any digging on Pubmed they will also find that it's well known in many autoimmune diseases that patients have increased viral load and titers to intracellular pathogens, just like in ME. Not sure if anyone's mentioned this before here on PR.

    While the debate and research over whether ME and many autoimmune diseases are caused or driven by pathogens will continue I think we should take a page from the autoimmune disease community, get treatments as soon as possible that target the autoimmune pathology of the disease so we can return to a pseudo-normal life while the scientific community continues to elucidate what is actually causing it.
     
    Last edited: Nov 11, 2015
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  7. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    @leokitten
    Interesting.
    The researchers at griffith were trying to find a difference in nk function between ME and other autoimmune disorders . I know they were looking into comparing nk function with MS and RA in some sort of study. They have found that nk bright cells ate the specific nk cell thats abnormal so from memory they wanted to compare nk function as well a nk bright and dim cells .

    Im not sure they did this research as they seem to have gone in the direction of studying cytokines .
     

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