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Natural Killer Cell Deficiency anyone?

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by RUkiddingME, Oct 17, 2011.

  1. RUkiddingME

    RUkiddingME Senior Member

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    Hello everyone:

    I have had every possible tests done through a Fatigue Clinic in the US and the most alarming result for me was my Natural Killer Cell level;

    Less than 8 LU30 = decreased activity
    8-170 LU30= Normal Activity
    more than 170 LU30= Increased activity

    My level was "6"

    This is what is says below my result:

    Natural killer cells, a component of the cell-mediated arm of the immune system, mediate destruction of some types of tumor cells and virus-infected cells. Decreased NK cytotoxicity is associated with impaired immune suveillance, and may explain a predisposition to malignancies and viral infections.

    Any one else have levels this low and should I be worried???
  2. alex3619

    alex3619 Senior Member

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    Hi Calgarynat, low NK cell activity (usually measured as cytotoxicity activity) is an extremely common finding in ME and CFS. It is so common that it is being considered as a biomarker and a number of research teams are looking into it in the USA, Japan and Australia. Klimas is one of the researchers in the USA.

    I think I have read of lower results than yours.

    This is a hot area of research. One Japanese study showed that improving NKCC (NK cell cytotoxicity) reduced symptoms, but this is still early in the research . I don't have references handy, I am in the process of shutting down my current computer and setting up a new one - but there are one or more threads on this on Phoenix Rising.

    The Australian research is pointing to an actual deficiency of one type of NK cell (called dim I think, the other is bright). I think this refers to how they look under an optical microscope, but thats just a guess.

    This marker is indeed worrying, but only because it might be a core problem in ME and CFS. Most of us have it to some degree. I have not personally been tested however.

    Bye
    Alex
  3. RUkiddingME

    RUkiddingME Senior Member

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    Thank you Alex for that information. I feel a little better knowing that it is that common. I have started taking Maitake d fraction (mushroom) supplement as I read it can help increase NK cell activity. I also just read the thread about Dr. Peterson's latest update and NK cells was a big part of the article. Hopefully we'll get closer to some concrete proof with this type of testing that might help us suffereres in getting closer to some answers.

    Ciao
    Nat
  4. searcher

    searcher

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    NK cell function does seem to be the best biomarker we have so far. My level was a 7, and my doctor said that single digits were pretty common in the patients he sees, so you are definitely not alone. No one has found a reliable way to increase our levels (I think because we really need to fix the mysterious, underlying cause,) but the mushroom supplements, astralagus, and whey protein have studies showing they can increase NK function.
    cheer
  5. u&iraok

    u&iraok Senior Member

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    Also, Blue-Green Algae, aka Aphanizomenon flos-aquae or AFA, increases NK function:

    Olena likes this.
  6. Athene

    Athene Never give up

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    If you have low NK cells you must get a good western blot test for Lyme disease done. That's the commonest cause of LOW NK absolute number and low NK activity.
  7. Tristen

    Tristen Senior Member

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    I stay between 1-4. Last one about 6 months ago was 1. Goes without saying that I remain vigilant for cancer and precursors.
  8. RUkiddingME

    RUkiddingME Senior Member

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    Thanks for the all the information! I did get tested twice for Lyme and thankfully came back normal. I do show antibodies or slightly elevated titers for Coxsackie B3, HHV6 and EBV.
  9. FernRhizome

    FernRhizome Senior Member

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    NK cell testing, any lab?

    Hi, does anyone know if it matters what lab does the NK cell testing? Or is it a very routine test that can be done anywhere?
  10. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Bond uni study tested NK activity, NK DIM cell activity, NK bright cell activity
    reference range 13.8-34.8 60-88 5-10
    dec 2009 33 76.9 4.32 i was on famvir previous 12 months and feeling dam good at this stage as number shows this.
    May10 6 82.1 1 I had stopped after famvir 12 months but relapsed and felt like crap
    Dec10 51.91 73 1.95 I was on famvir and cycloferon.

    I think this shows in me that antiviral famvir helps improve nk function and cycloferon is an additive effect. The nk bright cells are the things they are finding abnormal in cfs and hardest to try to change with treatment, but general nk activity can be improved.

    cheers!!!
  11. Daffodil

    Daffodil Senior Member

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    i had NK cell function of "2". i was pretty much on my deathbed. antivirals/lyme treatment will raise them higher....but i think only HIV meds will bring them back to healthy levels, which is 60 - 80 i think. i was 60 in my last test.

    ampligen will also do it.
  12. matt

    matt

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    Some thoughts on nk cells. Low nk function was found in CFS patients in Japan in the 1980s, and it was therefore named low natural killer cell syndrome. However i think over time japanese researchers moved away from this, and my vague understanding is that they do not place much emphasis on the immune system now, i think their focus is the brain.
    When i lived in Japan in the mid 90s and came down with cfs i had a nk function test and it was low, 6%.
    I think nk cell function is important for cfs, and reading the norwegian research I hypothesise as follows. An initial immune insult, virus, vaccination or chemicals triggers a chronic humoral th2 response, because of this nk cell activity is driven low, allowing chronic and latent infections which keep the negative cycle going. I've recently had a vaccination, and i relapsed, probably because my b cell humoral immunity got activated.
    This is why i think the b cell depleting drug works, it breaks this cycle.
    Based on personal experience i would be careful with mushrooms extracts as they boost humoral th2 immunity as well as nk cells, my condition worsened in particular food allergies
  13. Tristen

    Tristen Senior Member

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    Me too Matt. I learned long ago to stay away from all Immune stimulants, and many of the modulators as well. That includes the mushroom extracts like AHCC, etc.
  14. RUkiddingME

    RUkiddingME Senior Member

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    It's so hard to know what to do. I go to a Fibro and Fatigue Center in the US (now called Chronicity) and I've been put on maitake d fraction, anti-viral (natural ingredients plus 1,500 mg of N-Acetyl L Cysteine plus artemisin. I'm still bed ridden. I'm tempted to stick with some good old natural coconut oil which is popular for its anti-viral benefits. What is a girl to do!
  15. kurt

    kurt Senior Member

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  16. Nielk

    Nielk

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    I am wondering if there is anything new since the last posting on this subject?

    I just got my result of NK cell LU30 function. It is a 3 with reference range 8-170.

    My doctor gave me a "mushroom extract" supplement but, after reading previous posts here I am weary to try it.
  17. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    it would be interesting to see your nk function before and after the mushroom extract.
    Whats the name of the supplement?
    Im using beta glucan to try and help immune function now but mainly low neutrophils.
    Immunovir slightly increased my nk numbers but now i dont have access to nk function testing.
  18. Nielk

    Nielk

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    It is.called Lank. It's from his office but when I google it, I can't find it.
  19. SOC

    SOC Moderator and Senior Member

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    I think Dr Klimas uses AHCC to improve NK cell function. It might be worth trying if you haven't already.
    heapsreal likes this.
  20. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    At the moment its too expensive for me to use long term. Plus im going to try and cull my supps some.
    SOC likes this.

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