The last time I tried high dose quercetin, I found it overstimulated me during the day, and gave me some insomnia, so I stopped taking it. Apparently quercetin is a monoamine oxidase (MAO) inhibitor. MAO inhibitors are known for causing overstimulation/insomnia. However, maybe there's some way to prevent or counter quercetin's overstimulating/insomnia effects, by taking something which counters quercetin's MAO inhibition. In other words, take something that increases MAO production at the same time that you take quercetin. That should cancel out the overstimulation/insomnia effect of quercetin. Note that quercetin inhibits MAO-A much more than MAO-B; so we want to find an MAO-A booster to counter quercetin's stimulating effect. MAO production boosters potentially include: copper boosts MAO in general, progesterone boosts MAO-B (but progesterone unfortunately activates XMRV, so this defeats the object!), retinoic acid boosts MAO-B, dexamethasone (a corticosteroid) boosts MAO-A, Rauwolfia serpentina (a herb, but apparently not used much due to side effects) boosts MAO-A. I cannot find any other MAO-A boosters at the moment.